Incepta Pharmaceuticals Ltd.
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Caution is advised when consuming alcohol with Denosis 120. Please consult your doctor.
Denosis 120 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful ... View More
Denosis 120 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.... View More
Denosis 120 does not usually affect your ability to drive.
Denosis 120 is safe to use in patients with kidney disease. No dose adjustment of Denosis 120 is recommended.
Denosis 120 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Denosis 120 may not be neede... View More
Denosis 120 is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones st... View More
Uses of Denosis 120
Side effects of Denosis 120
- Musculoskeletal (bone, muscle or joint) pain
- Pain in extremity
- Nerve pain
- Urinary tract infection
How to use Denosis 120
Your doctor or nurse will guide you how to use this medicine.
How Denosis 120 works
Denosis 120 is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
What if you forget to take Denosis 120?
If you miss a dose of Denosis 120, please consult your doctor.
- Xgeva Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
- Take calcium and vitamin D to help build your bones when taking Xgeva Solution for Injection.
- Do not take if you are pregnant or plan to become pregnant.
- May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
- Xgeva Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
- Tell your doctor if you develop a rash while taking Xgeva Solution for Injection.
Osteoporosis, treatment of men and postmenopausal women with osteoporosis who are at high risk for fracture; treatment to increase bone mass in men at h... View More
Administer SC in upper arm, upper thigh, or abdomen; do NOT administer intradermally, IM, or IV Administer calcium and vitamin D as needed to treat or ... View More
Denosumab 60mg Subcutaneous Osteoporosis 60 mg SC every 6 months Supplement with calcium 1000 mg/day and vitamin D 400 IU/day Aromatase Inhibitor... View More
Renal Impairment: Based on the available safety and efficacy data in the elderly, no dosage adjustment is required in patients with renal impairment. P... View More
Clinically significant hypersensitivity to denosumab or to any of the components. Hypocalcemia.
Mode of Action
Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to receptor activator of nuclear factor kappa-... View More
Correct hypocalcemia prior to initiation of therapy. Patients should receive Ca & vit D supplements during treatment (unless hypercalcemia is present). ... View More
>10% Back pain (34.7%),Extremity pain (11.7%) 1-10% Musculoskeletal pain (7.6%),Hypercholesterolemia (7.2%),Cystitis (5.9%),Upper respiratory tract... View More
Pregnancy Category Note
Pregnancy Contraindicated Based on findings in animals and its mechanism of action, denosumab can cause fetal harm when administered to a pregnant w... View More
Increased risk of serious infections w/ immunosuppressive agents.Denosumab did not affect the pharmacokinetics of midazolam, a drug metabolised by cytoc... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More