Denosis 6060mg/ml
Injection
Incepta Pharmaceuticals Ltd.
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| Alcohol | CAUTION Caution is advised when consuming alcohol with Denosis 60. Please consult your doctor. |
| Pregnancy | UNSAFE Denosis 60 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful e... View More |
| Breastfeeding | SAFE IF PRESCRIBED Denosis 60 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. |
| Driving | SAFE Denosis 60 does not usually affect your ability to drive. |
| Kidney | SAFE IF PRESCRIBED Denosis 60 is safe to use in patients with kidney disease. No dose adjustment of Denosis 60 is recommended. |
| Liver | SAFE IF PRESCRIBED Denosis 60 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Denosis 60 may not be needed ... View More |
Introduction
Denosis 60 is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones str... View More
Uses of Denosis 60
- Osteoporosis
Side effects of Denosis 60
- Musculoskeletal (bone, muscle or joint) pain
- Pain in extremity
- Nerve pain
- Constipation
- Rash
- Urinary tract infection
How to use Denosis 60
Your doctor or nurse will guide you how to use this medicine.
How Denosis 60 works
Denosis 60 is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
What if you forget to take Denosis 60?
If you miss a dose of Denosis 60, please consult your doctor.
- Xgeva Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
- Take calcium and vitamin D to help build your bones when taking Xgeva Solution for Injection.
- Do not take if you are pregnant or plan to become pregnant.
- May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
- Xgeva Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
- Tell your doctor if you develop a rash while taking Xgeva Solution for Injection.
Indication
Osteoporosis, treatment of men and postmenopausal women with osteoporosis who are at high risk for fracture; treatment to increase bone mass in men at h... View More
Administration
Administer SC in upper arm, upper thigh, or abdomen; do NOT administer intradermally, IM, or IV Administer calcium and vitamin D as needed to treat or ... View More
Adult Dose
Denosumab 60mg Subcutaneous Osteoporosis 60 mg SC every 6 months Supplement with calcium 1000 mg/day and vitamin D 400 IU/day Aromatase Inhibitor... View More
Renal Dose
Renal Impairment: Based on the available safety and efficacy data in the elderly, no dosage adjustment is required in patients with renal impairment. P... View More
Contraindication
Clinically significant hypersensitivity to denosumab or to any of the components. Hypocalcemia.
Mode of Action
Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to receptor activator of nuclear factor kappa-... View More
Precaution
Correct hypocalcemia prior to initiation of therapy. Patients should receive Ca & vit D supplements during treatment (unless hypercalcemia is present). ... View More
Side Effect
>10% Back pain (34.7%),Extremity pain (11.7%) 1-10% Musculoskeletal pain (7.6%),Hypercholesterolemia (7.2%),Cystitis (5.9%),Upper respiratory tract... View More
Pregnancy Category Note
Pregnancy Contraindicated Based on findings in animals and its mechanism of action, denosumab can cause fetal harm when administered to a pregnant w... View More
Interaction
Increased risk of serious infections w/ immunosuppressive agents.Denosumab did not affect the pharmacokinetics of midazolam, a drug metabolised by cytoc... View More
Alternative brand for Denosis 60
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More