General Pharmaceuticals Ltd.
Additional OffersShow all
It is not known whether it is safe to consume alcohol with Prugen 1. Please consult your doctor.
Information regarding the use of Prugen 1 during pregnancy is not available. Please consult your doctor.
Prugen 1 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Prugen 1 may cause side effects which could affect your ability to drive. Prugen 1 may cause dizziness and tiredness, especially on the first day of tre... View More
Prugen 1 should be used with caution in patients with severe kidney disease. Dose adjustment of Prugen 1 may be needed. Please consult your doctor.
Prugen 1 should be used with caution in patients with severe liver disease. Dose adjustment of Prugen 1 may be needed. Please consult your doctor. Limit... View More
Prugen 1 is a prescription medicine used in the treatment of constipation. It increases the release of certain chemical that improves the movement of fo... View More
Uses of Prugen 1
Side effects of Prugen 1
- Abdominal pain
How to use Prugen 1
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prugen 1 may be taken with... View More
How Prugen 1 works
Prugen 1 indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.
What if you forget to take Prugen 1?
If you miss a dose of Prugen 1, skip it and continue with your normal schedule. Do not double the dose.
- Prugen 1 helps treat chronic constipation and improve bowel movements, when laxatives have failed to provide adequate relief.
- It can be taken with or without food, at any time of the day.
- It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you.
- Inform your doctor if your constipation has not improved even after four weeks of taking this medication.
Chronic idiopathic constipation.
May be taken with or without food.
Oral Chronic idiopathic constipation Adult: 2 mg once daily. Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. He... View More
Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily. Patient on dialysis: Contraindicated.
Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum,... View More
Mode of Action
Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility.
Patient w/ history of arrhythmias or ischaemic CV disease, severe and unstable concomitant disease (e.g. cancer, AIDS, neurological or psychiatric, pulm... View More
Nervous: Headache, dizziness, fatigue, malaise, tremors. CV: Palpitations. GI: Nausea, abdominal pain and distention, diarrhoea, vomiting, flatulence,... View More
May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentra... View More
Alternative brand for Prugen 1