Introduction
Diprivan 1% is a general anesthetic. It is used in major surgical procedures. It allows the procedures to be carried out without pain and distress. This injection is used in a hospital setting only.
Diprivan 1% is used in general anesthesia. It causes loss of consciousness which is reversible. It is administered under the supervision of a healthcare professional.
The most common side effects include headache, vomiting, and nausea. This Diprivan 1% is safe to use in pregnancy, breastfeeding mothers, patients of liver and kidney disease. Inform your doctor if you are on any medications or have any known allergy to this medicine before the start of the procedure.
It is not advised to consume alcohol after you have been administered. Driving should not be done as this medicine may cause sleepiness and may impair your ability to think or react. It is also advised not to operate machinery because of these effects.
Side effects of Diprivan 1%
Common
- Nausea
- Headache
- Vomiting
- Local site pain
- Slow heart rate
- Decreased blood pressure
How to use Diprivan 1%
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How Diprivan 1% works
Diprivan 1% is a general anaesthetic. It works by causing reversible loss of consciousness. This allows surgical procedures to be carried out without pain and distress.
Indication
General anaesthesia, Sedation
Adult Dose
Intravenous
Induction and maintenance of general anaesthesia
Adult: Induction: 40 mg by inj or infusion every 10 sec. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg.
Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg.
Sedation
Adult: In diagnostic and surgical procedures: Initially, 6-9 mg/kg/hr by infusion given for 3-5 minutes or an alternative dose of 0.5-1 mg/kg by slow inj over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hr infusion. Reduce maintenance dose by 20% for high-risk patients needing sedation.
For ventilated patients: 0.3-4 mg/kg/hr by infusion. Monitor lipid concentrations if duration of sedation lasts >3 days.
Child Dose
Intravenous
Anesthesia
Induction
3-16 years: 2.5-3.5 mg/kg IVP over 20-30 sec
Maintenance
2 months to 16 years: 0.125-0.3 mg/kg/min IV
Contraindication
Electroconvulsive therapy, obstetrics. Sedation in children <16 yr. Pregnancy, lactation.
Mode of Action
Short-acting, lipophilic sedative/hypnotic; causes global CNS depression, presumably through agonist actions on GABAa receptors.
Precaution
Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr.
Lactation: Excreted in breast milk; effect on nursing infant not known
Side Effect
>10%
Hypotension (peds 17%; adults 3-26%),Apnea lasting 30-60 sec (peds 10%; adults 24%),Apnea lasting >60 sec (peds 5%; adults 12%),Movement (peds 17%; adults 3-10%),Injection site burning/stinging/pain (peds 10%; adults 18%)
1-10%
Respiratory acidosis during weaning (3-10%),Hypertriglyceridemia (3-10%),Hypertension (peds 8%),Rash (peds 5%; adults 1-3%),Pruritus (1-3%),Arrhythmia (1-3%),Bradycardia (1-3%),Cardiac output decreased (1-3%; concurrent opioid use increases incidence).Tachycardia (1-3%)
<1%
Arterial hypotension,Anaphylaxis,Asystole,Bronchospasm,Cardiac arrest,Seizures,Opisthotic rxn,Pancreatitis,Pulmonary edema,Phlebitis,Thrombosis,Renal tubular toxicity
Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis.
Interaction
Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.