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Dorinem 500500mg/vial

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ACI Limited
Generic: Doripenem
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descriptionSafety Advices
Consuming alcohol with Dorinem 500 does not cause any harmful side effects.
Dorinem 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, t... View More
Dorinem 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.... View More
It is not known whether Dorinem 500 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and... View More
Dorinem 500 should be used with caution in patients with kidney disease. Dose adjustment of Dorinem 500 may be needed. Please consult your doctor.
Dorinem 500 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Dorinem 500 may not be neede... View More
descriptionMedical Overview


Dorinem 500 is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, ... View More

Uses of Dorinem 500

  • Severe bacterial infections

Side effects of Dorinem 500

  • Vomiting
  • Nausea
  • Injection site reactions (pain, swelling, redness)

How to use Dorinem 500

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Dorinem 500 works

Dorinem 500 is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them t... View More

What if you forget to take Dorinem 500?

If you miss a dose of Dorinem 500, please consult your doctor.

quick tipsQuick Tips
  • Dorinem 500 is an antibiotic that's usually only given in the hospital for serious infections.
  • It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes. In severe cases, it may be given slowly for 3 to 4 hours by intravenous ... View More
  • Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication.
  • Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools.
  • Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
descriptionBrief Description


Intra-abdominal infections, Bacterial infections, Septicemia, Nosocomial pneumonia, Urinary tract infections, Pyelonephritis


Reconstitution: Reconstitute 500 mg vial w/ 10 mL of sterile water for inj or NaCl 0.9% inj to form a susp containing 50 mg/mL. Further dilute the rec... View More

Adult Dose

Intravenous Complicated intra-abdominal infections Adult: 500 mg 8 hrly infused over 1 hr for 5-14 days. May switch to an appropriate oral therapy, af... View More

Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Renal impairment: CrCl (ml/min) 30-50 250 mg every 8 hr by IV infusion over 1 hr 11-29 250 mg every 12 hr by IV infusion over 1 hr


Hypersensitivity; anaphylactic reactions to beta-lactams.

Mode of Action

Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacte... View More


May decrease serum concentration of valproic acid to below therapeutic range thus increasing risk of breakthrough seizure; consider alternative antimicr... View More

Side Effect

>10% Headache (4-16%),Nausea (4-12%),Diarrhea (6-11%) 1-10% Anemia (2-10%),Phlebitis (4-8%),Rash (1-5%),Pruritus (3%),Transaminases elevated (1-2%)... View More

Pregnancy Category Note

Pregnancy Category: B Lactation: unknown if excreted in breast milk; use caution


Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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