Doripen500mg/vial
Injection
Eskayef Pharmaceuticals Ltd.
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| Alcohol | SAFE Consuming alcohol with Doripen does not cause any harmful side effects. |
| Pregnancy | SAFE IF PRESCRIBED Doripen is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there... View More |
| Breastfeeding | SAFE IF PRESCRIBED Doripen is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. |
| Driving | CONSULT YOUR DOCTOR It is not known whether Doripen alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and rea... View More |
| Kidney | CAUTION Doripen should be used with caution in patients with kidney disease. Dose adjustment of Doripen may be needed. Please consult your doctor. |
| Liver | SAFE IF PRESCRIBED Doripen is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Doripen may not be needed in the... View More |
Introduction
Doripen is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urin... View More
Uses of Doripen
- Severe bacterial infections
Side effects of Doripen
- Vomiting
- Nausea
- Injection site reactions (pain, swelling, redness)
How to use Doripen
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Doripen works
Doripen is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to su... View More
What if you forget to take Doripen?
If you miss a dose of Doripen, please consult your doctor.
- Doripen is an antibiotic that's usually only given in the hospital for serious infections.
- It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes. In severe cases, it may be given slowly for 3 to 4 hours by intravenous ... View More
- Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication.
- Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools.
- Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
Indication
Intra-abdominal infections, Bacterial infections, Septicemia, Nosocomial pneumonia, Urinary tract infections, Pyelonephritis
Administration
Reconstitution: Reconstitute 500 mg vial w/ 10 mL of sterile water for inj or NaCl 0.9% inj to form a susp containing 50 mg/mL. Further dilute the rec... View More
Adult Dose
Intravenous Complicated intra-abdominal infections Adult: 500 mg 8 hrly infused over 1 hr for 5-14 days. May switch to an appropriate oral therapy, af... View More
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment: CrCl (ml/min) 30-50 250 mg every 8 hr by IV infusion over 1 hr 11-29 250 mg every 12 hr by IV infusion over 1 hr
Contraindication
Hypersensitivity; anaphylactic reactions to beta-lactams.
Mode of Action
Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacte... View More
Precaution
May decrease serum concentration of valproic acid to below therapeutic range thus increasing risk of breakthrough seizure; consider alternative antimicr... View More
Side Effect
>10% Headache (4-16%),Nausea (4-12%),Diarrhea (6-11%) 1-10% Anemia (2-10%),Phlebitis (4-8%),Rash (1-5%),Pruritus (3%),Transaminases elevated (1-2%)... View More
Pregnancy Category Note
Pregnancy Category: B Lactation: unknown if excreted in breast milk; use caution
Interaction
Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.
Alternative brand for Doripen
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More