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Epleron 5050mg

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Incepta Pharmaceuticals Ltd.
Generic: Eplerenone
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descriptionSafety Advices
Epleron 50 may cause excessive drowsiness with alcohol.
Epleron 50 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, th... View More
Information regarding the use of Epleron 50 during breastfeeding is not available. Please consult your doctor.
Epleron 50 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Epleron 50 should be used with caution in patients with kidney disease. Dose adjustment of Epleron 50 may be needed. Please consult your doctor. Use of ... View More
Epleron 50 should be used with caution in patients with liver disease. Dose adjustment of Epleron 50 may be needed. Please consult your doctor. Use of E... View More
descriptionMedical Overview


Epleron 50 is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It is also used ... View More

Uses of Epleron 50

  • Hypertension (high blood pressure)
  • Edema

Side effects of Epleron 50

  • Dizziness
  • Diarrhea
  • Nausea
  • Cough
  • Flu-like symptoms
  • Fatigue
  • Increased potassium level in blood
  • Increased creatinine level in blood

How to use Epleron 50

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epleron 50 may be taken wi... View More

How Epleron 50 works

Epleron 50 is a potassium-sparing diuretic. It lowers blood pressure and swelling by removing the extra water and electrolytes from the body without los... View More

What if you forget to take Epleron 50?

If you miss a dose of Epleron 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to you... View More

quick tipsQuick Tips
  • Epleron 50 helps remove fluid from your body when used with other drugs.
  • It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Epleron 50 affects you.
  • It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
  • Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine.
  • Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
descriptionBrief Description


Hypertension, Heart failure, Congestive heart failure, Left ventricular dysfunction, Acute myocardial infarction


May be taken with or without food.

Adult Dose

Hypertension (HTN) Initial 50 mg PO qDay; may increase to 50 mg PO q12hr; may take up to four weeks for full therapeutic response; hyperkelemia may occ... View More

Renal Dose

Renal Impairment Contraindicated if CrCl <50 mL/min or serum creatinine >2 mg/dL in males or >1.8 mg/dL in females


For all patients: Serum potassium >5.5 mEq/L at initiation; CrCl ?30 mL/min; concomitant use of strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazol... View More

Mode of Action

Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney, GI tract) and nonepithelial (e.g. heart, blood vessels, brain) tissues... View More


Measure serum potassium levels before starting therapy, within the first wk, and periodically thereafter. Increased risk of hyperkalaemia in patients wi... View More

Side Effect

1-10% Hyperkalemia (2-10%),Increased risk of hyperkalemia with presence of renal dysfunction 1-3% Dizziness,Fatigue/malaise,Abdominal pain,Diarrhea... View More

Pregnancy Category Note

Pregnancy Available data from published case reports on eplerenone use during pregnancy are insufficient to establish a drug-associated risk of major b... View More


Concomitant use with CYP3A4 Inhibitors (e.g. ketoconazole, voriconazole, itraconazole, fluconazole, clarithromycin, diltiazem saquinavir, verpamil, rito... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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