Introduction
Ambrisan is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to... View More
Uses of Ambrisan
Side effects of Ambrisan
How to use Ambrisan
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ambrisan may be taken with... View More
How Ambrisan works
Ambrisan is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). Th... View More
What if you forget to take Ambrisan?
If you miss a dose of Ambrisan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your ... View More
Indication
Pulmonary Arterial Hypertension
Administration
May be taken with or without food: Swallow whole.
Adult Dose
Indicated for WHO group 1 PAH to 1) improve exercise ability and delay clinical worsening; and 2) in combination with tadalafil to reduce the risks of d... View More
Child Dose
Safety and efficacy not established
Renal Dose
Dose adjustment in patients with mild or moderate renal impairment is therefore not required. There is no information on the exposure to ambrisentan in ... View More
Contraindication
Ambrisentan may cause fetal harm when administered to a pregnant woman. Ambrisentan is contraindicated in women who are or may becom... View More
Mode of Action
High affinity endothelin (ETa) receptor subtype antagonist, resulting in inhibition of vasoconstriction.
Precaution
Fluid Retention: Peripheral oedema has been observed with ERAs including ambrisentan. It is also a clinical consequence of PAH and worsening PAH. Pulm... View More
Side Effect
>10% Peripheral edema (17%),Headache (15%) 1-10% Nasal congestion (6%),Palpitations (5%),Constipation (4%),Dyspnea (4%),Flushing (4%),Abdominal pai... View More
Pregnancy Category Note
Pregnancy Based on data from animal reproduction studies, fetal harm may occur when administered to a pregnant woman and is contraindicated during preg... View More
Interaction
Cyclosporine Exposure to ambrisentan may be increased (approximately 2-fold). Limit the dosage of ambrisentan to 5 mg daily with coadministration. R... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More