G Quinine300mg/5ml

Indication

Malaria, Nocturnal leg cramps

Adult Dose

Intravenous Malaria Adult: As diHCl: Initially, 20 mg/kg to max 1.4 g over 4 hr w/ maintenance infusion started after 8 hr. Maintenance infusions: 1... View More

Child Dose

Intravenous Malaria Child: <5 mg/kg/hr by slow IV infusion.

Renal Dose

Renal impairment: Severe: Reduce maintenance dose to 5-7 mg/kg of quinine salt 8 hrly.

Contraindication

Hypersensitivity to quinine, mefloquine or quinidine. Patients w/ nocturnal leg cramps; prolonged QT interval, tinnitus or optic neuritis, myasthenia gr... View More

Mode of Action

Quinine is a cinchona alkaloid and a 4-methanolquinoline. It rapidly acts on blood schizontocide by interfering w/ lysosomal function or nucleic acid sy... View More

Precaution

Patients w/ cardiac conduction defects, heart block or AF. Pregnancy and lactation. Monitoring Parameters Monitor for signs of cardiotoxicity. Monitor b... View More

Side Effect

<1% Flushing of the skin,Anginal symptoms,Fever,Rash,Pruritus,Hypoglycemia,Epigastric pain,Hemolysis in G6PD deficiency,Thrombocytopenia,Hepatitis,Nigh... View More

Interaction

Reduced renal clearance of amantadine. Reduced clearance w/ cimetidine. Increased anticoagulant effect of warfarin and other anticoagulants. Reduced pla... View More