Holicef IV is an antibiotic belonging to the cephalosporin group, which is used to treat bacterial infections in your body. It is effective in infection... View More
Uses of Holicef IV
Side effects of Holicef IV
How to use Holicef IV
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Holicef IV works
Holicef IV is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for the... View More
What if you forget to take Holicef IV?
If you miss a dose of Holicef IV, please consult your doctor.
Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure I... View More
IV/IM Administration IV: Infuse intermittently over 30 minutes IM: Inject deep into large muscle mass
Susceptible infections IV/IM 1-2 g/day, up to 4 g/day for severe infections. Intra-abdominal Infections Complicated, mild-to-moderate, community ac... View More
Children: IV, IM: 50–75 mg/kg/day, max 2 g/day q24h 50 mg/kg, max 1 g, 1–3 doses IM for AOM q24h 100 mg/kg/day for meningitis, max 4 g/day q12h
Renal impairment: CrCl (ml/min) <10 Max: 2 g daily.
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of... View More
Mode of Action
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in ... View More
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection. Lactation: Drug enters breast milk in low concentrat... View More
>10% Induration after IM injection (5-17%) 1-10% Eosinophilia (6%),Thrombocytosis (5%),Diarrhea (3%),Elevated hepatic transaminases (3%),Leukopenia... View More
Pregnancy Category Note
Pregnancy category: B Lactation: Drug enters breast milk in low concentrations; use with caution
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effe... View More