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Irinotecan20mg/ml

Infusion
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Generic: Irinotecan Hydrochloride Trihydrate
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descriptionSafety Advices
AlcoholAlcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Irinotecan. Please consult your doctor.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Irinotecan is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it i... View More
BreastfeedingBreastfeeding
UNSAFE
Irinotecan is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
DrivingDriving
UNSAFE
Irinotecan may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
KidneyKidney
SAFE IF PRESCRIBED
Irinotecan is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Irinotecan may not be needed... View More
LiverLiver
CONSULT YOUR DOCTOR
There is limited information available on the use of Irinotecan in patients with liver disease. Please consult your doctor.
descriptionMedical Overview

Introduction

Irinotecan is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Irinote... View More

Uses of Irinotecan

  • Cancer of colon and rectum

Side effects of Irinotecan

Common
  • Fatigue
  • Nausea
  • Vomiting
  • Weakness
  • Hair loss
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Decreased white blood cell count (neutrophils)
  • Decreased appetite
  • Mucosal inflammation

How to use Irinotecan

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Irinotecan works

Irinotecan is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cance... View More

What if you forget to take Irinotecan?

If you miss a dose of Irinotecan, please consult your doctor.

quick tipsQuick Tips
  • Irinotecan is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
  • It is given via a drip into a vein (intravenous infusion).
  • It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or f... View More
descriptionBrief Description

Indication

Carcinoma of the colon or rectum

Administration

Reconstitution: Dilute in 5% dextrose injection (preferred) or 0.9% sodium chloride injection to a final concentration of 0.12-2.8 mg/ml.

Adult Dose

Intravenous Colorectal Cancer Indicated as first-line therapy (with 5-fluorouracil and leucovorin) for metastatic colorectal cancer (CRC); it is also ... View More

Child Dose

Not recommended

Contraindication

Patients with a known hypersensitivity to the drug or its excipients.

Mode of Action

Irinotecan, a derivative of camptothecin, works by inhibiting the enzyme topoisomerase I thereby interfering with the coiling and uncoiling of DNA durin... View More

Precaution

Early diarrhea is usually transient and infrequently severe. It may be accompanied by cholinergic symptoms of rhinitis, increased salivation, miosis, la... View More

Side Effect

>10% Anemia (>90%),Leukopenia (>90%),Neutropenia (>90%),Thrombocytopenia (>90%),Elevated bilirubin (88%),Diarrhea (85%),Nausea (79%),Asthenia (70%),Abd... View More

Interaction

Diuretics increase risks of dehydration secondary to vomiting/diarrhoea; prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia; prochl... View More

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descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More