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Jo-1 ANTIBODY

Autoimmune Antibody Test for Polymyositis & Dermatomyositis

Sample Type

blood

Fasting Required

Description

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). Evaluating patients with clinical features of idiopathic inflammatory myositis, especially those with clinical features. suggestive of anti-synthetase syndrome or interstitial lung disease.

Covid Safety

Assured

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Counselling

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Albumin Globulin Ratio

Includes 1 test

How our test process works!

Step 1

Sample Collection

Vaccinated Phlebotomists collects from syringe in the barcoded vials

Step 2

Sample Storage

Only vaccinated phelbos are assigned orders

Step 3

High Tech Facility

Lab ingests the sample into processing machines which are 100% automated

Step 4

Accurate Digital Reports

The reports are generated by the processing machines and clinically correlated by doctors

Overview

Risk assessment

Risk Assessment

Conditions Associated:
- Polymyositis (PM)
- Dermatomyositis (DM)
- Antisynthetase syndrome (a subset of myositis with lung involvement, arthritis, and fever)
- Interstitial lung disease (ILD)
- Other autoimmune diseases like systemic lupus erythematosus (SLE) or systemic sclerosis (rarely)
Symptoms that May Indicate a Need for the Test:
- Muscle weakness (especially proximal muscles)
- Muscle pain
- Skin rashes (if dermatomyositis is suspected)
- Joint pain or arthritis
- Shortness of breath (suggesting interstitial lung disease)
- Fever

Ranges

Normal Range

Typically <1.0 U/mL or <20 IU/mL, but varies by laboratory. Always interpret results in context with reference values provided by the testing lab.

Test result interpretation

Interpretation of Results

Negative/Normal (<1.0 U/mL or <20 IU/mL, depending on the lab method)
- No detectable Jo-1 antibodies
- Unlikely to have myositis or antisynthetase syndrome
Positive (>1.0 U/mL or >20 IU/mL, depending on the lab method)
- Suggests polymyositis, dermatomyositis, or antisynthetase syndrome
- May indicate interstitial lung disease
- Not always diagnostic alone; clinical symptoms and other tests (such as muscle biopsy, electromyography, or lung function tests) are needed
Borderline or Low Positive
- May require repeat testing or correlation with other autoimmune markers.