Overview

Purpose:
The test evaluates the immune system function by analyzing specific immune cells and antibodies in peripheral blood to diagnose or monitor Primary Immunodeficiency Disorders (PIDs).

Risk Assessment

• Indications: Recurrent infections, poor response to vaccines, family history of immunodeficiency, failure to thrive, or unexplained immune abnormalities.

• Risks: Minimal risks associated with blood draw (e.g., mild pain, bruising, infection at puncture site).

Normal Range:

• Depends on specific immune parameters measured (e.g., lymphocyte subsets like CD3, CD4, CD8, B cells, NK cells).

• Normal ranges vary by age and lab standards; typically provided with the test report.

Interpretation

• Low or abnormal lymphocyte subsets or antibody levels may indicate specific types of Primary Immunodeficiency.

• Patterns help classify PID (e.g., T-cell defects, B-cell defects, combined immunodeficiencies).

• Requires clinical correlation and sometimes further specialized testing for confirmation.

Sample Type:
Peripheral blood (usually collected in an EDTA tube).