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Lodiben 5/20
Eskayef Pharmaceuticals Ltd.
Generic: Amlodipine + Benazepril Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Lodiben 5/20.
CONSULT YOUR DOCTOR
Lodiben 5/20 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Lodiben 5/20 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Lodiben 5/20 may cause side effects which could affect your ability to drive.
As it is advisable to exercise caution when driving with Lodiben 5/20.
CAUTION
Lodiben 5/20 should be used with caution in patients with kidney disease. Dose adjustment of Lodiben 5/20 may be needed. Please consult your doctor.
Regular monitoring of blood pressure is recommended for better dose adjustment.
CAUTION
Lodiben 5/20 should be used with caution in patients with liver disease. Dose adjustment of Lodiben 5/20 may be needed. Please consult your doctor.
Lodiben 5/20 is started at a lower dose in patients with liver disease and further increased slowly with careful monitoring.
Medicine Overview of Lodiben 5/20 5mg+20mg Capsule
Introduction
Lodiben 5/20 is used to treat hypertension (high blood pressure). This is a combination of two medicines that controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke. You can take Lodiben 5/20 at any time of day, with or without food, but it is best to take it at the same time each day. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood...
... Show moreUses of Lodiben 5/20
- Hypertension (high blood pressure)
Side effects of Lodiben 5/20
Common
- Ankle swelling
- Headache
- Tiredness
- Palpitations
- Increased potassium level in blood
- Sleepiness
- Cough
- Taste change
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Decreased blood pressure
- Upset stomach
How to use Lodiben 5/20
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lodiben 5/20 may be taken with or without food, but it is better to take it at a fixed time.
How Lodiben 5/20 works
Lodiben 5/20 is a combination of two medicines: Amlodipine and benazepril which lower blood pressure effectively. It works by relaxing blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently.
Quick Tips
- You have been prescribed Lodiben 5/20 for the treatment of high blood pressure.
- Lowering blood pressure reduces chance of future heart attack & strokes.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Do not take Lodiben 5/20 if you are pregnant or planning for pregnancy.
Brief Description
Indication
Oral
Hypertension
Adult: Amlodipine component: 2.5-10 mg once daily; benazepril component: 10-40 mg once daily. Titrate dose gradually according to response.
Elderly: Initiate with 2.5 mg Amlodipine component once daily.
Hepatic impairment: Initiate with 2.5 mg Amlodipine component once daily. Titrate combination slowly in severe hepatic impairment.
Administration
Additive effect when used with catecholamine depleting drugs; monitor for hypotension and/or marked bradycardia. If used with clonidine, clonidine withdrawal should occur a few days after withdrawal of the beta-blocker to prevent rebound hypertension; if replacing clonidine by beta-blocker, beta-blocker should be introduced only after clonidine administration has stopped for several days. Concurrent use with prostaglandin synthase inhibiting drugs (e.g. indomethacin) may reduce the hypotensive effects of beta-blockers.
Adult Dose
Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death. Caution in elderly, renal or hepatic impairment, congestive heart failure, severe aortic stenosis, unilateral or bilateral renal artery stenosis, use during surgery or anaesthesia. Amlodipine+Benazepril can cause symptomatic hypotension, especially in patients with salt/volume depletion. ACE inhibitors (ACEi) have been associated with cholestatic jaundice and fulminant hepatic necrosis; discontinue treatment if patient develops jaundice/marked elevation of liver enzymes. Monitor renal function and serum potassium periodically. Angioedema of the face, extremities, lips, tongue, glottis, larynx and intestinal angioedema have...
... Show moreRenal Dose
Amlodipine is a dihydropyridine calcium antagonist. It lowers BP by relaxing the coronary vascular smooth muscles and producing coronary vasodilation; through inhibition of transmembrane Ca ion influx into vascular smooth muscle and cardiac muscle. It is also a peripheral vascular vasodilator. Benazepril and its active metabolite benazeprilat inhibit ACE, which results in decreased plasma angiotensin II and thus leading to decreased aldosterone secretion.
Contraindication
Safety and efficacy in paediatric patients have not been established.
Mode of Action
May be taken with or without food.
Precaution
Hypertension
Side Effect
Renal impairment: Decrease dose if CrCl <30 mL/min, severe liver impairment, or coadministered with diuretic
Pregnancy Category Note
>10%
Amlodipine
Peripheral edema (2-15%),Pulmonary edema (7-15%)
1-10%
Amlodipine
Abdominal pain (1.6%),Dizziness (1.1-3.4%),Dyspepsia (1-2%),Fatigue (4.5%),Flushing (0.7-2.6%),Headache (7.3%),Male sexual dysfunction (1-2%),Muscle cramps (1-2%),Nausea (2.9%),Palpitation (0.7-4.5%),Rash (1-2%),Somnolence (1-2%),Weakness (1-2%)
Benazepril
ARF if renal artery stenosis
Cough (1-10%),Dizziness (4%),Fatigue (2%),Headache (6%),Nausea (1%),Postural dizziness (2%),Serum creatinine increased (2%),Somnolence (2%)
Potentially Fatal: Analphylactoid reactions, angioedema, Stevens-Johnson syndrome.
Interaction
Patients with history of angioedema; pregnancy, lactation.
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