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Midothal

Capsule-(50mg)
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Incepta Pharmaceuticals Ltd.

Generic: Thalidomide

1 Capsule
৳ 27.27
৳ 30
9% OFF

Medicine Overview of Midothal 50mg Capsule

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Introduction

Midothal is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works. Midothal should be taken on empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include headache, sleepiness, nausea, rash, and breathlessness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Regular blood tests are required to check your blood cells while on treatment. It might cause blood clots, and your doctor might prescribe some other medicine to prevent this. Before taking it, tell your doctor if have heart disease, liver, or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You are advised to drink plenty of fluids to stay hydrated while taking this medicine.

Uses of Midothal

  • Multiple myeloma
  • Lepra reaction

Side effects of Midothal

Common
  • Headache
  • Sleepiness
  • Nausea
  • Rash
  • Weakness
  • Dizziness
  • Edema (swelling)
  • Loss of appetite
  • Decreased white blood cell count
  • Decreased calcium level in blood
  • Weight gain
  • Fatigue
  • Muscle weakness
  • Fever
  • Anxiety
  • Blood clots
  • Dry skin
  • Weight loss
  • Confusion
  • Decreased white blood cell count (neutrophils)
  • Neuropathy
  • Constipation
  • Tremor

How to use Midothal

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Midothal is to be taken empty stomach.

How Midothal works

Midothal modulates the activity of body's immune system and helps indirectly attacking the cancer cells. It also stops the growth of blood vessels in cancer.

What if you forget to take Midothal?

If you miss a dose of Midothal, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • Use an effective method of contraception for 4 weeks before starting treatment, during treatment, and until 4 weeks after stopping treatment.
  • Before taking thalidomide inform your doctor if you have had a heart attack, have ever had a blood clotting related disorder, or if you smoke, have high blood pressure or high cholesterol levels, have existing slow heart rate (this may be symptoms of bradycardia), existing neuropathy i.e. tingling, abnormal co-ordination or pain in your hands or feet, sleepiness, a condition called Tumor Lysis Syndrome, severe infections.
  • Consult a doctor if you develop allergic reaction such as rash, itching, swelling, dizziness or trouble breathing during thalidomide therapy.
  • Avoid donating blood during thalidomide treatment and for 1 week after stopping treatment.
  • Do not drive or operate machinery as thalidomide may cause fatigue, dizziness, somnolence and blurred vision.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Brief Description

Indication

Multiple myeloma, Erythema nodosum leprosum

Administration

Should be taken on an empty stomach. Take on an empty stomach at least 1 hr after a meal, w/ a full glass of water.

Adult Dose

Oral Erythema nodosum leprosum (Type 2) Adult: 100-300 mg once daily at bedtime, reduced gradually by 50 mg every 2-4 wk once a satisfactory reponse is achieved. Not for monotherapy if moderate or severe neuritis present. Max: 400 mg/day. Patients < 50 kg: Initially, 100 mg daily. Multiple myeloma Adult: Initial dose of 200 mg once daily, increased by 100 mg at wkly intervals according to patient tolerance. Max: 800 mg daily.

Contraindication

Hypersensitivity. Pregnancy and lactation.

Mode of Action

Thalidomide is a synthetic glutamic acid derivative immunomodulator with anti-inflammatory, antiangiogenetic, sedative and hypnotic activity.

Precaution

All females of childbearing potential must use 2 reliable forms of contraception simultaneously 4 wk before starting therapy, during and 4 wk after therapy is discontinued. Therapy to be stopped immediately if pregnancy occurs. Male: Use of barrier methods of contraception if partner is of child-bearing potential. Do not donate blood or sperm during therapy. Patient should not drive or operate machinery. Discontinue therapy if any skin rash develops. Do not resume therapy if the rash is exfoliative, purpuric, or bullous, or if Stevens-Johnson syndrome or toxic epidermal necrolysis suspected. Lactation: not known if excreted in breast milk, not recommended

Side Effect

>10% Somnolence (37%),Rash (21%),Edema (57%),Hypotension (16%),Leukopenia (17-35%),Neutropenia (31%),Increased bilirubin (14%),Myalgia (17%),Arthralgia (13%),Hematuria (11%),Thrombosis/embolism (23%),Headache (12%),Dyspnea (42%) 1-10% Asthenia (8%),General pain (8%),Impotence (8%),Malaise (8%),Pruritus (8%),Xerostomia (8%),Flatulence (8%),Tooth pain (4%),Impotence (3-8%),Vertigo (8%),Constipation (4%),Diarrhea (4%),Neck rigidity (4%) Frequency Not Defined Photosensitivity,Bradycardia,Hypo/hypertension,Peripheral neuropathy,Neutropenia Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis and blood dyscrasias.

Interaction

Thalidomide enhances sedative activity of barbiturates, alcohol, chlorpromazine and reserpine. Avoid use of other drugs that have the potential to cause peripheral neuropathy. Increased risk of thromboembolic events with darbepoetin-alfa and doxorubicin. Potentially Fatal: Increased risk of bone marrow supression with peg interferon alfa.

Buy Midothal from Arogga

In Bangladesh, you can get the original Midothal. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Midothal in Bangladesh?

The latest price of Midothal in Bangladesh is 27.27৳. You can buy Midothal at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Midothal may cause excessive drowsiness with alcohol.
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UNSAFE
Midothal is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
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CONSULT YOUR DOCTOR
Midothal is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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UNSAFE
Midothal may cause side effects which could affect your ability to drive. You may experience side effects, such as dizziness, tiredness, sleepiness or blurred vision with Midothal and this may affect your ability to drive.
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SAFE IF PRESCRIBED
Midothal is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Midothal may not be needed in these patients. Please consult your doctor.
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SAFE IF PRESCRIBED
Midothal is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Midothal may not be needed in these patients. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.