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Naurif
Square Pharmaceuticals PLC.
Generic: Granisetron
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Naurif. Please consult your doctor.
SAFE IF PRESCRIBED
Naurif is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Naurif is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Naurif does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Naurif is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Naurif may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Naurif is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Naurif may not be needed in these patients. Please consult your doctor.
Medicine Overview of Naurif 1mg/ml Injection
Introduction
Naurif is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy. Naurif will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember, you should not stop taking this medicine suddenly without talking to your...
... Show moreUses of Naurif
- Nausea
- Vomiting
Side effects of Naurif
Common
- Sleepiness
- Weakness
- Headache
- Constipation
- Diarrhea
How to use Naurif
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naurif may be taken with or without food, but it is better to take it at a fixed time.
How Naurif works
Naurif is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
What if you forget to take Naurif?
If you miss a dose of Naurif, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Naurif for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.
- Unlike some other nausea medicines, the side effects for Naurif are relatively mild.
- It is fast-acting and starts working within 30 minutes.
- If you vomit within one hour of taking a dose, take another dose.
- Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.
Brief Description
Indication
Nausea and vomiting, Chemotherapy-induced nausea and vomiting, Post-operative nausea and vomiting
Administration
May be taken with or without food. Take up to 1 hr before chemotherapy.
Adult Dose
Chemotherapy Induced Nausea & Vomiting Oral 1 mg PO 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemotherapy IV 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy Radiation-Induced Nausea & Vomiting 2 mg PO, 1 hr before radiation treatment Postoperative Nausea & Vomiting Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia Treatment: 1 mg (undiluted) IV push over 30 seconds Elderly: Chemotherapy Induced Nausea & Vomiting Oral: 2 mg 1 hr...
... Show moreChild Dose
Chemotherapy Induced Nausea & Vomiting
<2 years: Safey and efficacy not established
2-16 years: As adults; 0.01 mg/kg infused over 5 min or direct inj over 30 sec, 30 min before chemotherapy
Oral administration: Currently FDA-approved for IV administration in children; safety and efficacy of oral administration is not established
Postoperative Nausea & Vomiting
Safety and efficacy not established
Not approved for postoperative N/V in pediatric patients because of lack of efficacy and QT prolongation observed in clinical trials
Renal Dose
Renal impairment
IV
Severe (CrCl <30 mL/min): Total clearance was not affected in patients with severe renal failure who received a single 40 mcg/kg IV dose
PO
No dosage adjustment required
Contraindication
Hypersensitivity.
Mode of Action
Granisetron is a selective 5-HT3-receptor antagonist with little or no affinity for other serotonin receptors. It blocks serotonin in the chemoreceptor zone.
Precaution
Subacute intestinal obstruction or ileus. Moderate to severe hepatic impairment. Congenital long QT syndrome or other risk factors for QT prolongation (e.g. electrolyte abnormalities and cumulative high-dose anthracycline therapy). Pregnancy, lactation.
Lactation: excretion in milk unknown; use with caution
Side Effect
>10%
Headache (10-21%)
1-10%
Diarrhea (1-9%),Constipation (3-18%),Asthenia (5%),Somnolence (10%),Sedation (10%),Drowsiness (10%)
Frequency Not Defined
Anxiety,Fatigue,Malaise,Increased LFTs
Interaction
Phenobarbital may induce metabolism of granisetron.
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