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Nordrine
Incepta Pharmaceuticals Ltd.
Generic: Ephedrine Hydrochloride
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Nordrine. Please consult your doctor.
CONSULT YOUR DOCTOR
Nordrine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Nordrine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Nordrine does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Nordrine in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Nordrine in patients with liver disease. Please consult your doctor.
Medicine Overview of Nordrine 25mg/5ml Injection
Introduction
Nordrine is used to treat the low blood pressure commonly seen following spinal anesthesia. It raises blood pressure by narrowing the blood vessels of the heart. Nordrine is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Your doctor may advise for regular monitoring of blood pressure while you are taking this medicine. It may cause side effects like high blood pressure and insomnia (difficulty in sleeping). This...
... Show moreUses of Nordrine
- Hypotension following spinal anesthesia
Side effects of Nordrine
Common
- Systemic hypertension (high blood pressure)
- Insomnia (difficulty in sleeping)
How to use Nordrine
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Nordrine works
Nordrine works on the blood vessels and increases the blood flow to heart and lungs, thereby improving the disease condition.
What if you forget to take Nordrine?
If you miss a dose of Nordrine, please consult your doctor.
Quick Tips
- It is usually given as a slow injection into your veins by a doctor or healthcare professional.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
- Inform your doctor if you are taking or have recently taken medication to treat severe depression.
Brief Description
Indication
Bronchial asthma, Hypotension, Diabetic neuropathic oedema
Administration
May be taken with or without food.
IV Preparation
Must be diluted before administration as an IV bolus to 5 mg/mL by withdrawing 50 mg (1 mL) dilute with 9 mL 0.9% NaCl or D5W
Adult Dose
Oral
Acute bronchospasm
Adult: As ephedrine HCl: 15-60 mg tid. Max: 150 mg/day.
Diabetic neuropathic oedema
30-60 mg 3 times/day.
Elderly: Initial: 50% of adult dose.
Parenteral
Reversal of spinal or epidural anaesthesia-induced hypotension
Adult: As ephedrine HCl: 3-6 mg by slow IV inj every 3-4 min as required. Max total dose: 30 mg.
Elderly: Same as adult dose.
Child Dose
Oral
Acute bronchospasm
Child: As ephedrine HCl:
1-5 yr 15 mg tid;
6-12 yr 30 mg tid;
>12 yr Same as adult dose.
Parenteral
Reversal of spinal or epidural anaesthesia-induced hypotension
Child: 0.5 mg/kg or 16.7 mg/m2 4-6 hrly by SC or IM inj or
alternatively, 0.75 mg/kg or 25 mg/m2 4 times daily by SC or IV inj.
Contraindication
Hypersensitivity. Hypertension, thyrotoxicosis, BPH. Lactation.
Mode of Action
Ephedrine has both alpha- and beta-adrenergic acitivity with pronounced stimulating effects on the CNS. It increases cardiac output, induces peripheral vasoconstriction, bronchodilation, reduces intestinal tone and motility, and relaxes the bladder while contracting the sphincter muscle. It also has stimulant action on the resp center and dilates the pupil witho affecting light reflexes.
Precaution
Ischaemic heart disease, hyperthyroidism, diabetes mellitus, hypertension, angle-closure glaucoma, renal impairment; prostatic enlargement; pregnancy, elderly.
Lactation
Unknown if excreted in breast milk
Side Effect
Gastrointestinal disorders: Nausea, vomiting
Cardiac disorders: Tachycardia, palpitations (thumping heart), reactive hypertension, bradycardia, ventricular ectopics, heart rhythm/rate variability
Nervous system disorders: Dizziness
Psychiatric disorders: Restlessness
Potentially Fatal: Delusions, hallucinations. Seen with hypersensitivity and overdosage. Acute CNS and CVS stimulation presenting as vomiting, fever, hypertension, psychosis. Cardiac arrhythmias.
Pregnancy Category Note
Pregnancy
Ephedrine crosses the placenta; used at deliver for prevention and/or treatment of maternal hypotension associated with spinal anesthesia
Fetal/neonatal adverse reactions
Cases of potential metabolic acidosis in newborns at delivery with maternal ephedrine exposure have been reported in the literature
These reports describe umbilical artery pH of ?7.2 at the time of delivery
Monitor newborn for signs and symptoms of metabolic acidosis
Monitoring of infant’s acid-base status is warranted to ensure that an episode of acidosis is acute and reversible
Lactation
Unknown if excreted in breast milk
Interaction
Reduces antihypertensive effect of bethanidine and guanethidine. May increase clearance of dexamethasone. Increased incidence of adverse effects when used with theophylline.
Potentially Fatal: Severe HTN when combined with MAOIs or withi 2 wk of discontinuance of MAOI treatment. Increased risk of arrhythmias with cardiac glycosides, quinidine or tricyclic antidepressants. Increased vasoconstriction or pressor effects with ergot alkaloids or oxytocin.
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