Introduction
Arduan belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care.
Arduan is administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms.
The medicine is generally well-tolerated with little or no side effects. However, it may cause injection site reactions (such as pain, redness, and swelling), rash, and allergic reactions in some people. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Before using it, you should let your doctor know if you have any medical conditions or disorders. You should also tell your doctor all the other medicines you are using or taking. Pregnant and breastfeeding women should consult their doctors before using this medicine.
Uses of Arduan
- Skeletal mucle relaxation during surgery
Side effects of Arduan
Common
- Skin rash
- Increased saliva production
- Injection site reactions (pain, swelling, redness)
- High blood pressure
How to use Arduan
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Arduan works
Arduan is a muscle relaxant. It works by relaxing the muscles during a surgical procedure by blocking the transmission of impulses from the nerves to the muscles.
Indication
Muscle relaxant in general anaesthesia, Facilitate endotracheal intubation
Adult Dose
Intravenous
Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation
Adult: Initial dose: 80-100 mcg/kg. Subsequent doses: 10-20 mcg/kg.
Initial dose following suxamethonium admin or in patients at high risk: 50-60 mcg/kg.
Initial dose for caesarean section: 35 mcg/kg.
Contraindication
Hypersensitivity.
Mode of Action
Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker. It does not have significant CV adverse effects or histamine-related effects.
Precaution
Pulmonary disease, respiratory insufficiency, asthma, neuromuscular disease, dehydration, severely ill patients, hepatic or renal impairment. Doses in obese patients should be based on patient's ideal body weight. Pregnancy, lactation.
Side Effect
Transient hypotension, bradycardia, reduced cardiac output.
Potentially Fatal: Anaphylactic reactions and malignant hyperthermia.
Interaction
Actions antagonised by cholinesterases and long term carbamazepine, phenytoin or corticosteroids usage. Enhanced block when used with drugs that have neuromuscular blocking activity such as lidocaine, quinidine, verapamil and aminoglycosides.
Potentially Fatal: Effects enhanced by volatile inhalational anaesthetics, ketamine (IV), antiarrhythmics, antibacterials, K depleting diuretics, parenteral Mg salts.