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Premarin
Radiant Pharmaceuticals Ltd.
Generic: Estrogens
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Premarin. Please consult your doctor.
CONSULT YOUR DOCTOR
Premarin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Premarin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Premarin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
UNSAFE
Premarin is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
UNSAFE
Premarin is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Premarin 0.625mg Tablet
Introduction
Premarin is a female sex hormone (estrogen). It is a part of female hormonal replacement therapy which helps in treating estrogen deficiency symptoms like hot flushes (red and warm face) and vaginal dryness. Premarin is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get...
... Show moreUses of Premarin
- Hormone replacement therapy
Side effects of Premarin
Common
- Bloating
- Breast pain
- Hair loss
- Headache
- Irregular vaginal bleeding
- Nausea
- Stomach cramp
- Vomiting
How to use Premarin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Premarin may be taken with or without food, but it is better to take it at a fixed time.
How Premarin works
Premarin is a mixture of estrogens (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).
What if you forget to take Premarin?
If you miss a dose of Premarin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Premarin as a part of hormone replacement therapy to relieve symptoms of menopause.
- It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
- Take it at the same time everyday to help you remember to take it.
- Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Premarin.
- It may increase the risk of breast cancer. Have regular breast examinations.
- Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.
Brief Description
Indication
Breast cancer, Prostate cancer, Hormone replacement therapy, Oral contraceptives
Adult Dose
Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae 0.3 mg PO once daily in either continuous daily regimen or cyclic regimen (25 days on, 5 days off); adjusted PRN; use lowest dose that control symptoms; may be given daily if medical assessment warrants it Female Hypogonadism 0.3-0.625 mg PO once daily in cyclic regimen (3 weeks on, 1 week off); may be titrated every 6-12 months; adjusted PRN; add progestin treatment should be added to maintain bone mineral density once skeletal maturity achieved Osteoporosis Prophylaxis 0.3 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN based...
... Show moreContraindication
Severe liver impairment; breast carcinoma; thromboembolic disorders; CV disease; undiagnosed vag bleeding; estrogen-dependent neoplasms; hypersensitivity; pregnancy.
Mode of Action
Estrogens modulate pituitary secretion of gonadotropins, leutinising hormones and follicle-stimulating hormones through -ve feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during oestrogen replacement therapy.
Precaution
Asthma, epilepsy, migraine; heart or kidney dysfunction; CV disease; cerebrovascular disorders; diabetes, hypercalcaemia; gall bladder disease; porphyria. Childn. Lactation.
Lactation: Use controversial; estrogens are excreted into breast milk in small quantities; use with caution
Side Effect
>10%
Abdominal pain (15-17%),Back pain (13-14%),Breast enlargement,Breast tenderness (7-12%),Headache (26-32%),Arthralgia (7-14%),Pharyngitis (10-12%),Sinusitis (6-11%),Diarrhea (6-7%)
1-10%
Depression (5-8%),Dizziness (4-6%),Nervousness (2-5%),Flatulence (6-7%),Vaginitis (5-7%),Leukorrhea (4-7%),Leg cramps (3-7%),Increased cough (4-7%),Pruritus (4-5%)
Frequency Not Defined
Amenorrhea,Breakthrough bleeding,Corneal curvation change,Melasma,Spotting,Vaginal moniliasis,Weight changes
Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.
Pregnancy Category Note
Pregnancy Category: X
Lactation: Controversial; estrogens are excreted into breast milk in small quantities, use caution
Interaction
Rifampicin, barbiturates increase rate of metabolism.
Potentially Fatal: May reduce the efficacy of anticoagulants.
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