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Arolef

Tablet-(100mg)
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General Pharmaceuticals Ltd.

Generic: Leflunomide

1 Tablet
৳ 1
৳ 1

Medicine Overview of Arolef 100mg Tablet

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Introduction

Arolef is used in the treatment of rheumatoid arthritis and psoriatic arthritis. It helps in slowing down the progression of the disease and provide relief from pain, swelling, and redness. Arolef can be taken with or without food. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Using this medicine may cause some common side effects such as nausea, headache, dyspepsia, rash, diarrhea, increased liver enzymes, and respiratory tract infection. Consult with your doctor if any of these side effects do not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms. To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problems with your heart, kidneys, or liver. Also, tell your doctor of all the other medicines you are taking. Your doctor may recommend regular blood tests to check and make sure the medicine is not harming your liver or effecting your blood counts. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of Arolef

  • Rheumatoid arthritis
  • Psoriatic arthritis

Side effects of Arolef

Common
  • Nausea
  • Headache
  • Rash
  • Diarrhea
  • Increased liver enzymes
  • Respiratory tract infection

How to use Arolef

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arolef may be taken with or without food, but it is better to take it at a fixed time.

How Arolef works

Arolef blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain autoimmune diseases. It suppresses the underlying disease process, rather than simply treating the disease.

What if you forget to take Arolef?

If you miss a dose of Arolef, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • You have been prescribed Arolef to control the symptoms and slow down the progression of rheumatoid arthritis.
  • It will take 6-8 weeks for Arolef to work. Hence, keep taking the medicine.
  • Get blood tests done every 4 weeks. This is to make sure that Arolef is not harming your liver or blood counts.
  • Avoid alcohol when taking Arolef as it could harm your liver.
  • Do not take it during pregnancy or breastfeeding. Tell your doctor if you become pregnant while taking Arolef.
  • Arolef may increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you experience nausea or diarrhea.

Brief Description

Indication

Rheumatoid arthritis, Psoriatic arthritis

Administration

May be taken with or without food.

Adult Dose

Oral Rheumatoid arthritis; Psoriatic arthritis Adult: Loading dose: 100 mg once daily for 3 days. Maintenance: 10-20 mg once daily. Hepatic impairment: Contraindicated.

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Mild: No dosage adjustment needed. Moderate to Severe: Contraindicated.

Contraindication

Significant hepatic impairment, compromised immune function including bone marrow dysplasia or severe uncontrolled infection; concurrent vaccination with live vaccines. Pregnancy, lactation.

Mode of Action

Leflunomide is an immunomodulating agent and DMARD. It inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resulting in antiproliferative and anti-inflammatory effects.

Precaution

Renal and hepatic impairment; Women with childbearing potential. Caution should be taken for those female with child bearing potential who are not using reliable contraception and for the subject of renal insufficiency. Leflunomide should be stopped before becoming pregnant. Liver function should be monitored before starting treatment. Monitor blood counts and BP regularly. Avoid alcohol. Lactation: not known if excreted in breast milk

Side Effect

>10% Diarrhea (17%),Respiratory infections (15%) 1-10% (selected) Alopecia (10%),Hypertension (10%),Rash (10%),Nausea (9%),Bronchitis (7%),Headache (7%),Abdominal pain (5%),Abnormal LFT's (5%),Accidental injury (5%),Back pain (5%),Dyspepsia (5%),UTI (5%),Dizziness (4%),Infection (4%),Joint disorder (4%),Pruritus (4%),Weight loss (4%),Anorexia (3%),Cough (3%),Gastroenteritis (3%),Pharyngitis (3%),Stomatitis (3%),Tenosynovitis (3%),Vomiting (3%),Weakness (3%),Allergic reaction (2%),Chest pain (2%),Dry skin (2%),Eczema (2%),Pain (2%),Paresthesia (2%),Pneumonia (2%),Rhinitis (2%),Sinusitis (2%),Synovitis (2%) Potentially Fatal: Hepatotoxicity.

Interaction

Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs may increase the risk of hepatotoxicity. Rifampicin increases serum levels of the active metabolite. Potentially Fatal: May enhance the adverse effects of live vaccines.

Buy Arolef from Arogga

In Bangladesh, you can get the original Arolef. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Arolef in Bangladesh?

The latest price of Arolef in Bangladesh is 1৳. You can buy Arolef at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
It is unsafe to consume alcohol with Arolef.
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UNSAFE
Arolef is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
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CONSULT YOUR DOCTOR
Arolef is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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UNSAFE
Arolef may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
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CAUTION
Arolef should be used with caution in patients with kidney disease. Dose adjustment of Arolef may be needed. Please consult your doctor.
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UNSAFE
Arolef is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.