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Replet 75
Healthcare Pharmaceuticals Ltd.
Generic: Clopidogrel
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Replet 75. Please consult your doctor.
SAFE IF PRESCRIBED
Replet 75 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Replet 75 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Replet 75 does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Replet 75 in patients with kidney disease. Please consult your doctor.
SAFE IF PRESCRIBED
Replet 75 is safe to use in patients with liver disease. No dose adjustment of Replet 75 is recommended.
Medicine Overview of Replet 75mg Tablet
Introduction
Replet 75 is an antiplatelet medicine or a blood thinner that helps to prevent the formation of harmful blood clots in your blood vessels. This helps to lower the chances of you getting a heart attack or stroke. It is a widely used medicine for heart protection. Replet 75 is prescribed to people at high risk of heart disease. This includes people with peripheral vascular disease (blood circulation problems due to narrowing of blood vessels), recent heart attack or stroke, irregular heartbeats, and those who have undergone certain heart procedures like stenting. It is also used in combination with some...
... Show moreUses of Replet 75
- Prevention of heart attack and stroke
- Heart attack
- Peripheral vascular disease
Side effects of Replet 75
Common
- Bleeding
How to use Replet 75
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Replet 75 may be taken with or without food, but it is better to take it at a fixed time.
How Replet 75 works
Replet 75 is an antiplatelet medication. It works by preventing platelets from sticking together, thereby decreasing the formation of harmful blood clots. This lowers the chance of heart attack or stroke.
What if you forget to take Replet 75?
If you miss a dose of Replet 75, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- For best results, take it at the same time every day.
- Replet 75 increases your risk of bleeding. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
- Do not discontinue using the medicine without consulting your doctor as this may increase your chances of having another heart attack or stroke.
- If you are scheduled to undergo a surgery or dental treatment, you may be asked to stop taking Replet 75 temporarily.
Brief Description
Indication
Coronary Artery Disease, Acute coronary syndrome, Myocardial infarction, Peripheral vascular disease, Cerebrovascular disease, Atherosclerosis, Thromboembolic disorders, Unstable angina, Stroke
Administration
May be taken with or without food.
Adult Dose
Oral
Prophylaxis of thromboembolic disorders, Recent MI, Stroke, or Established Peripheral Arterial Disease, Coronary Artery Disease
Adult: 75 mg once daily.
Acute coronary syndrome
Adult: For ST-elevation MI: In combination w/ aspirin: 75 mg once daily.
75 years
No loading dose
75 mg for 14 days up to 12 months (if no bleeding)
For unstable angina, non-ST-elevation MI: In combination w/ aspirin: Initially, 300 mg loading dose, followed by 75 mg once daily for up to 12 mth.
Hepatic impairment: Use caution; experience limited
Renal Dose
Renal impairment: Dose adjustment not necessary
Contraindication
Hypersensitivity. Active pathological bleeding. admin within 7 days after MI and ischaemic stroke, coagulation disorders. Lactation.
Mode of Action
Clopidogrel inhibits adenosine diphosphate (ADP) from binding to its receptor sites on the platelets and subsequent activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion and aggregation.
Precaution
Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions; ulcer; renal and hepatic impairment; history of bleeding or haemostatic disorders. Pregnancy.
Lactation: Not known whether drug is excreted in breast milk; not recommended
Side Effect
1-10%
Upper respiratory tract infection (8.7%),Chest pain (8.3%),Headache (7.6%),Flulike syndrome (7.5%),Arthralgia (6%),Pain (6%),Dizziness (6%),Diarrhea (4.5%),Rash (4.2%),Rhinitis (4.2%),Depression (3.6%),Urinary tract infection (3.1%)
<1%
Severe neutropenia,Thrombotic thrombocytopenic purpura,Acute liver failure,Aplastic anemia,Hypotension,Hepatitis,Myalgia,Eczema,Erythema,Agranulocytosis
Potentially Fatal: Bleeding disorders including GI and intracranial haemorrhage. Blood dyscrasias.
Pregnancy Category Note
Pregnancy Available data from cases reported over two decades in published literature and postmarketing surveillance have not identified any drug-associated risks for major birth defects or miscarriage; there are risks to pregnant woman and fetus associated with myocardial infarction and stroke Myocardial infarction and stroke are medical emergencies; therapy for pregnant woman should not be withheld because of potential concerns regarding effects of clopidogrel on the fetus Labor or delivery Therapy during labor or delivery will increase risk of maternal bleeding and hemorrhage; avoid neuraxial blockade during clopidogrel use because of risk of spinal hematoma; when possible, discontinue therapy 5-7...
... Show moreInteraction
Co-admin with NSAIDs may increase the risk of stomach and intestinal bleeding. High-dose clopidogrel may lead to increased warfarin levels thus increasing the risk of bleeding. High-dose clopidogrel may also inhibit P450 (2C9), thus interfering with the metabolism of phenytoin, tamoxifen, torasemide, fluvastatin and some NSAIDs. Avoid c
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