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Restat 10
The Ibn Sina Pharmaceutical Ind. Ltd.
Generic: Rosuvastatin
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Restat 10. Please consult your doctor.
UNSAFE
Restat 10 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Restat 10 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Restat 10 does not usually affect your ability to drive.
CAUTION
Restat 10 should be used with caution in patients with kidney disease. Dose adjustment of Restat 10 may be needed. Please consult your doctor.
Use of Restat 10 is not recommended in patients with severe kidney disease.
CAUTION
Restat 10 should be used with caution in patients with liver disease. Dose adjustment of Restat 10 may be needed. Please consult your doctor.
Use of Restat 10 is not recommended in patients with severe liver disease and active liver disease.
Medicine Overview of Restat 10mg Tablet
Introduction
Restat 10 belongs to a group of medicines called statins. It is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Restat 10 is a widely prescribed medicine and is regarded as safe for long-term use. It can be taken with a meal or on an empty stomach. You can take it at any time of the day but try to take it at the same time each day. Most people with high...
... Show moreUses of Restat 10
- High cholesterol
- Prevention of heart attack and stroke
Side effects of Restat 10
Common
- Muscle pain
- Weakness
- Headache
- Abdominal pain
How to use Restat 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Restat 10 may be taken with or without food, but it is better to take it at a fixed time.
How Restat 10 works
Restat 10 is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required by the body to make cholesterol, thereby lowering "bad" cholesterol (LDL) and triglycerides and raising "good" cholesterol (HDL).
What if you forget to take Restat 10?
If you miss a dose of Restat 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses within 12 hours.
Quick Tips
- Restat 10 treats high cholesterol by lowering "bad" cholesterol (LDL) and triglycerides (fats). It should be taken in addition to regular exercise and low-fat diet.
- In general, Restat 10 is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.
- Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
- Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
- Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Restat 10 may cause an increase in your blood sugar level.
- Do not take Restat 10 if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Hyperlipidaemias, Primary hypercholesterolaemia (heterozygous familial hypercholesterolaemia), mixed dyslipidaemia, homozygous familial hypercholesterolaemia, Stroke prevention
Administration
May be taken with or without food.
Adult Dose
Oral
Hypercholesterolemia, Hypertriglyceridemia, hyperlipidemia, mixed dyslipidemiaProphylaxis of cardiovascular events in high-risk patients
Adult: Initially, 5 or 10 mg once daily, may increase dose at 4-wkly intervals to 20 mg daily if necessary.
Max: 40 mg once daily.
Active liver disease: Use is contraindicated
Child Dose
Oral
Child
Heterozygous familial hypercholesterolaemia: >10 yr Initially, 5 mg once daily, may be adjusted at intervals of at least 4 wk.
Max: 20 mg once daily.
Renal Dose
Renal impairment
Severe (CrCl 30mL/min/1.73m²: Dose adjustment not necessary
Contraindication
Severe renal impairment, active liver disease, unexplained persistent elevations of serum transaminases; hypersensitivity. Pregnancy, lactation.
Mode of Action
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. It increases the number of hepatic LDL receptors on the cell surface, enhancing uptake and catabolism of LDL. It also decreases apolipoprotein B, triglycerides and increases HDL.
Precaution
Patients w/ predisposing factors for myopathy (e.g. untreated hypothyroidism, renal impairment), history of chronic liver disease and alcoholism. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue treatment if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy.
Lactation
Contraindicated
Side Effect
>10%
Myalgia (3-13%)
1-10%
Arthralgia (10%),Diabetes mellitus, new onset (3%),Pharyngitis (9%),Headache (6%),Asthenia (up to 5%),Dizziness (4%),CPK increased (3%),Nausea (3%),Abdominal pain (2%),ALT increased (2%),Constipation (2%),Flulike illness (2%),UTI (2%)
<1%
Jaundice,Myopathy,Rhabdomyolysis
Potentially Fatal: Rhabdomyolysis with acute renal failure.
Interaction
May increase serum levels of warfarin and oral contraceptives. May increase serum levels w/ itraconazole, HIV protease inhibitors. May decrease serum levels w/ erythromycin and antacids. May increase risk of myopathy w/ fenofibrate, niacin.
Potentially Fatal: Increased risk of rhabdomyolysis w/ gemfibrozil and ciclosporin.
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