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Rituxim
Beacon Pharmaceuticals PLC
Generic: Rituximab
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Rituxim. Please consult your doctor.
CONSULT YOUR DOCTOR
Rituxim may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rituxim is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Rituxim alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Rituxim is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Rituxim may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Rituxim in patients with liver disease. Please consult your doctor.
Use of Rituxim is not recommended in patients with the active liver disease or those who had viral hepatitis as it can reactivate the infection.
Medicine Overview of Rituxim 100mg/10ml Injection
Introduction
Rituxim is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Rituxim is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can...
... Show moreUses of Rituxim
- Non-Hodgkin lymphoma (NHL)
- Rheumatoid arthritis
- Blood cancer (Chronic lymphocytic leukemia)
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
Side effects of Rituxim
Common
- Headache
- Weakness
- Edema (swelling)
- Infection
- Hair loss
- Itching
- Chills
- Febrile neutropenia
- Decreased white blood cell count (neutrophils)
- Infusion reaction
- Increased risk of infection
- Decreased blood cells (red cells, white cells, and platelets)
How to use Rituxim
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Rituxim works
Rituxim is a monoclonal antibody. It works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis and certain types of cancers.
What if you forget to take Rituxim?
If you miss a dose of Rituxim, please consult your doctor.
Quick Tips
- It is given as a drip (intravenous infusion) by your doctor or nurse.
- You may be given some painkillers, antihistamine and possibly steroids before the drip to help prevent infusion reaction.
- Your doctor may get blood tests done to check for hepatitis B before treatment and to monitor your blood cells during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Inform your doctor if you have any heart rhythm problems, if you are having surgery or if you plan to get any vaccinations.
Brief Description
Indication
Non-Hodgkin's lymphoma; follicular lymphoma
Administration
Reconstitution: Dilute the appropriate dose w/ sodium chloride 0.9% or glucose 5% to a final concentration of between 1 and 4 mg/mL.
IV Administration
Consider premedication (ie, paracetamol and diphenhydramine, or glucocorticoids for RA) before each infusion
Administer by slow IV infusion only; do not administer as an IV
First IV infusion rate: Start 50 mg/hr; increase by 50 mg/hr q30min, not to exceed 400 mg/hr
Subsequent IV infusions (90 minutes)
Standard IV infusions: Start 100 mg/hr, increase by 100 mg/hr q30min, not to exceed 400 mg/hr; institutional protocols may allow faster increments
Adult Dose
Intravenous Non-Hodgkin Lymphoma Recommended dose for NHL 375 mg/m² IV infusion according to the following schedules Relapsed or refractory low-grade or follicular, CD20-positive, B-cell NHL: Once weekly x4-8 doses Retreatment for relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL: Once weekly x4 doses Previously untreated, follicular, CD20-positive, B-cell NHL: Administer on Day 1 of each chemotherapy cycle for up to 8 doses; with complete or partial response, initiate maintenance 8 weeks following completion of combination chemotherapy as a single-agent q8weeks for 12 doses Nonprogressing, low-grade, CD20-positive, B-cell NHL, after first-line CVP chemotherapy: Following completion of 6-8 cycles of CVP...
... Show moreChild Dose
Safety and efficacy not established
Contraindication
Lactation. Type I hypersensitivity or anaphylactic reactions to murine proteins or component of the formulation.
Mode of Action
Rituximab is a chimeric monoclonal antibody to CD20 antigen which regulates cell cycle initiation. It binds to the antigen on the cell surface, activating complement-dependent B-cell cytotoxicity; and to human Fc receptors, mediating cell killing through an antibody-dependent cellular toxicity.
Precaution
Extensive tumor burden, pulmonary tumor infiltration or pulmonary insufficiency; history of cardiac disease; effective contraception during and up to 12 mth after treatment; pregnancy. Monitor CBC and platelet counts regularly. Premedication with analgesics, antihistamines and corticosteroids may be recommended. Monitor for signs of active infection or hepatitis in hepatitis B carriers. Discontinue treatment if viral hepatitis develops.
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10% NHL Angioedema (11%), hypotension (10%), Asthenia (26%), chills (33%), dizziness (10%), fever (53%), headache (19%) Pruritus (14%), rash (15%), Abdominal pain (14%), diarrhea (10%), nausea (23%), vomiting (10%) Leukopenia (14%), lymphopenia (48%), neutropenia (14%), thrombocytopenia (12%), Back pain (10%), myalgia (10%) Cough (13%), rhinitis (12%), Infection (31%), night sweats (15%) 1-10% NHL Edema,Flushing,Hypertension,Anxiety,Anemia,Elevated LDH,Hyperglycemia,Bronchospasm, dyspnea, sinusitis, throat irritation, urticaria,RA (Rituximab+Methotrexate vs Methotrexate Alone) Hypertension,Anxiety, asthenia, chills, migraine, paresthesia, pyrexia,Pruritus, urticaria,Dyspepsia, nausea, upper abd pain,Hypercholesterolemia,Arthralgia,Rhinitis, throat irritation, URI Frequency Not Defined Tumor lysis syndrome,Lymphoid malignancies,Hypogammaglobulinemia Potentially Fatal: Pulmonary or cardiac toxicity during infusion; severe mucocutaneous reactions; severe cytokine release syndrome...
... Show moreInteraction
Increased risk of renal toxicity w/ cisplatin.
Potentially Fatal: May decrease the efficacy of vaccines and increase the risk of infections in patients immunised w/ live vaccines.
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