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Oral
Adult: Up to 1 g daily.
Hyperphosphataemia in patients with chronic renal failure
Adult: Dose is adjusted to the individual patient's requirement. Up to 10 g/day may be given in divided doses with meals.
Max Dosage: 10 g daily in divided doses.
Contraindication
Hypersensitivity to aluminium salts.
Mode of Action
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Precaution
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Side Effect
Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.
Interaction
Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
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