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Stigmin

Name: Stigmin Neostigmine Methyl Sulphate Injection 500mcg/ml
Brand: EDCL
SKU: 17997
Price: 5.45 BDT
Availability: OutOfStock
Rating: 4.8 (1 reviews)

Injection-(500mcg/ml)

EDCL

Generic: Neostigmine Methyl Sulphate

1 Injection

৳ 5.45

৳ 6

9% OFF

Alternative Brands For Stigmin

Medicine Overview of Stigmin 500mcg/ml Injection

বাংলা

Introduction

Stigmin is a prescription medicine used in the treatment of myasthenia gravis (a disease causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), post-operative urinary retention and reversal of effect of skeletal muscle relaxants after surgery. Stigmin works by reducing and improving muscle weakness. It may be taken with or without food, preferably at the same time each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor. Some common side effects of using this medication are nausea, vomiting, abdominal cramps, increased production of saliva and diarrhea. It usually does not cause dizziness and sleepiness. But, if you feel ill, avoid doing any such work that requires focus and attention, such as driving or operating any machinery. Before taking Stigmin, it is better to inform your doctor if you are suffering from any kidney problems, parkinson's disease, asthma, or stomach disorders. Your blood pressure may decrease after taking this medicine, so it is better to monitor it and consult your doctor if it bothers you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Stigmin

Myasthenia gravis
Paralytic ileus
Post-operative urinary retention
Reversal of effect of skeletal muscle relaxant after surgery

Side effects of Stigmin

Common

Nausea
Vomiting
Abdominal cramp
Diarrhea

How to use Stigmin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Stigmin may be taken with or without food, but it is better to take it at a fixed time.

How Stigmin works

Stigmin is a reversible cholinesterase inhibitor. When taken by mouth it increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.

What if you forget to take Stigmin?

If you miss a dose of Stigmin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

Do not drink alcohol while taking this medicine as it may worsen the side effects.

Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Brief Description

Indication

Myasthenia gravis, Paralytic ileus, Post-op urinary retention, Reversal of nondepolarising neuromuscular blockade

Adult Dose

Parenteral Myasthenia gravis Adult: 0.5-2.5 mg by IM or SC inj, doses are given at intervals according to response up to a total daily dose of 5-20 mg. Paralytic ileus and postoperative urinary retention Adult: 0.5-2.5 mg by SC or IM inj, as required. Reversal of neuromuscular blockade Adult: 0.03-0.07 mg/kg by inj over 60 sec, as required. Not to exceed 0.07 mg/kg or a cumulative total of 5 mg, whichever dose is less Inject by slow IV over at least 1 minute

Child Dose

Parenteral Myasthenia gravis Child: <12 yr 0.2-0.5 mg, repeated at suitable intervals throughout the day. Paralytic ileus and postoperative urinary retention Child: 0.125-1 mg by SC or IM inj. Intravenous Reversal of neuromuscular blockade Child: 0.05-0.07 mg/kg by inj over 60 sec, as required. Intramuscular Neonatal myasthenia gravis Child: Initially, 0.1 mg, followed by 0.05-0.25 mg or 0.03 mg/kg 2-4 hrly.

Renal Dose

Renal impairment: Dose adjustment may be required.

Contraindication

Mechanical GI or urinary tract obstruction, peritonitis.

Mode of Action

Neostigmine reversibly inhibits acetylcholinesterase and thus potentiates the nicotinic and muscarinic effects of acetylcholine. This facilitates the transmission of impulses across myoneural junction.

Precaution

Patient w/ bronchial asthma, CV disorders (e.g. bradycardia, recent MI, hypotension), peptic ulcer disease, vagotonia, epilepsy, parkinsonism, hyperthyroidism. Patient who underwent recent intestinal or bladder surgery. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor ECG, BP and heart rate esp w/ IV use. Lactation: Unknown if distributed in human breast milk; use caution

Side Effect

Allergic: Allergic reactions and anaphylaxis Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension (predominantly with parenteral dosage form) Respiratory: Increased oral, pharyngeal and bronchial secretions, and dyspnea; respiratory depression, respiratory arrest and bronchospasm have been reported following the use of the injectable form Dermatologic: Rash and urticaria Gastrointestinal: Nausea, emesis, flatulence, and increased peristalsis and salivation Genitourinary: Urinary frequency Musculoskeletal: Muscle cramps and spasms, arthralgia Miscellaneous: Diaphoresis, flushing and weaknes Potentially Fatal: Anaphylaxis.

Interaction

May reduce effects of anticholinergics. May increase effects of cholinergic agonists. Increased risk of bradycardia with digoxin, diltiazem, verapamil or beta-blockers without intrinsic sympathomimetic activity. Increased muscle weakness and decreased response to anticholinesterases with corticosteroids. May increase effects of depolarising neuromuscular blockers. Effects may be antagonised by drugs with neuromuscular blocking activity e.g. aminoglycosides, clindamycin, colistin, cyclopropane, halogenated inhalational anaesthetics. Effects may be reduced by quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, beta-blockers. Possible additive toxicity with ophthalmic use of anticholinesterases e.g. ecothiopate.

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Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

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Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

UNSAFE

Stigmin may cause excessive drowsiness with alcohol.

CONSULT YOUR DOCTOR

Stigmin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

SAFE IF PRESCRIBED

Stigmin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

CONSULT YOUR DOCTOR

It is not known whether Stigmin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

CAUTION

Stigmin should be used with caution in patients with kidney disease. Dose adjustment of Stigmin may be needed. Please consult your doctor. Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine.

SAFE IF PRESCRIBED

Stigmin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Stigmin may not be needed in these patients. Please consult your doctor.