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T-Zol IV
Popular Pharmaceuticals Ltd.
Generic: Tinidazole
Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking T-Zol IV may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR
T-Zol IV may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CAUTION
T-Zol IV should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
If a single dose of T-Zol IV is used, it is recommended to hold breastfeeding for 12-24 hours to allow the removal of the drug.
UNSAFE
T-Zol IV may cause side effects which could affect your ability to drive.
T-Zol IV may make you feel drowsy or gives you problems with coordination or sensation (e.g. numbness or weakness). This may affect your driving ability.
SAFE IF PRESCRIBED
T-Zol IV is safe to use in patients with kidney disease. No dose adjustment of T-Zol IV is recommended.
SAFE IF PRESCRIBED
T-Zol IV is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of T-Zol IV may not be needed in these patients. Please consult your doctor.
Medicine Overview of T-Zol IV 400mg/100ml Infusion
Introduction
T-Zol IV is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, and skin. T-Zol IV is also used in the treatment of dental infections, leg ulcers and pressure sores. This medicine should be taken with food, at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it is, but you should take this antibiotic exactly as prescribed by your doctor. Your...
... Show moreUses of T-Zol IV
- Bacterial infections
- Parasitic infections
Side effects of T-Zol IV
Common
- Headache
- Dryness in mouth
- Nausea
- Metallic taste
How to use T-Zol IV
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. T-Zol IV is to be taken with food.
How T-Zol IV works
T-Zol IV is an antibiotic. It kills the bacteria and other microorganisms that cause infections by damaging their DNA.
What if you forget to take T-Zol IV?
If you miss a dose of T-Zol IV, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- T-Zol IV treats infections caused by bacteria and parasites.
- It may also be used to prevent infections following surgery.
- Always take the complete course of treatment, as advised by your doctor, even if you feel better.
- It may cause side effects like nausea, stomach upset, and a metallic taste in the mouth.
- T-Zol IV used in a high dose or for a prolonged time increases the risk of side effects such as nerve damage. Take it only as prescribed by your doctor.
- Do not drink alcohol during or for 2-3 days after treatment with this medicine. You may develop nausea, vomiting, flushing and headache.
- Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.
Brief Description
Indication
Giardiasis, H. pylori infection, Surgical Prophylaxis, Bacterial vaginosis, Intestinal amoebiasis, Trichomoniasis, Acute necrotising ulcerative gingivitis, Hepatic amoebiasis
Administration
Should be taken with food. Take during or immediately after meals.
Adult Dose
Oral Bacterial vaginosis Adult: 2 g as single dose. May also be given as 2 g for 2 consecutive days or 1 g daily for 5 days. Anaerobic bacterial infections Adult: 2 g on the 1st day, followed by 1 g daily or 500 mg bid for 5-6 days. Prophylaxis of postoperative anaerobic bacterial infections Adult: 2 g as single dose 12 hr before surgery. Eradication of H. pylori associated with peptic ulcer disease Adult: 500 mg bid, given w/ clarithromycin and omeprazole for 7 days. Intestinal amoebiasis Adult: 2 g daily for 2 or 3 days. Hepatic amoebiasis Adult:...
... Show moreChild Dose
Oral
Intestinal amoebiasis
Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2 g/day.
Hepatic amoebiasis
Child: >3 yr 50-60 mg/kg daily for 5 days. Max: 2 g/day.
Giardiasis
Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day.
Renal Dose
Renal impairment: Haemodialysis: Additional dose equal to half the usual dose at the end of haemodialysis.
Contraindication
Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).
Mode of Action
Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.
Precaution
Patient w/ current or a history of blood dyscrasias. Pregnancy (2nd and 3rd trimester). Hepatic and renal impairment. Monitoring Parameters Monitor total and differential leukocyte counts. Closely monitor childn when treatment duration exceeds 3 days.
Lactation: discontinue nursing while taking drug & for 3 d after last dose
Side Effect
1-10%
Anorexia (2-3%),Constipation (<1%),Dizziness (<1%),Dysgeusia (4-6%),Dyspepsia (1-2%),Headache (<1%),Nausea (3-5%),Vomiting (1-2%),Weakness/fatigue/malaise (1-2%)
Frequency Not Defined
Ataxia,Candida overgrowth,Convulsions & transient peripheral neuropathy,Numbness & paresthesia,Diarrhea,Darkened urine,Tongue discoloration,Transient leukopenia/neutropenia
Potentially Fatal: Hypersensitivity.
Interaction
May potentiate the effects of oral anticoagulants resulting to prolonged prothrombin time.
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