Introduction
Augment 1.2 IV is a penicillin-type of antibiotic that helps your body fight infections caused by bacteria. It is used to treat infections of the lungs (e.g., pneumonia), ear, nasal sinus, urinary tract, skin and soft tissue. It will not work for viral infections such as the common cold.
Augment 1.2 IV is best taken with a meal to reduce the chance of a stomach upset. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back or worsen.
The most common side effects of this medicine include vomiting, nausea, and diarrhea. These are usually mild but let your doctor know if they bother you or will not go away.
Before taking it, let your doctor know if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your healthcare team know about all other medicines you are taking as they may affect, or be affected by, this medicine. This medicine is generally regarded as safe to use during pregnancy and breastfeeding if prescribed by a doctor.
Side effects of Augment 1.2 IV
How to use Augment 1.2 IV
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Augment 1.2 IV is to be taken with food.
How Augment 1.2 IV works
Augment 1.2 IV is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.
What if you forget to take Augment 1.2 IV?
If you miss a dose of Augment 1.2 IV, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Adults: PO: One 375 mg tablet 3 times a day. In severe infection one 625mg tablet 3 times a day or one 1gm tablet two times a day.
IV Injection: 1.2 g every 6-8 hours
Hepatic impairment: Dose with caution; monitor hepatic function regularly
Administration
Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
Adult Dose
History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.
Lactation: Drug excreted in breast milk; use caution
Renal Dose
Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Contraindication
Children: 125/31.25-, 250/62.5-mg/5-mL susp: 20–40 mg amoxicillin component/kg/day (max 1,500 mg/day) q8h
200/28.5-, 400/57-mg/5-mL susp: 25-45 mg amoxicillin component/kg/day (max 1,750 mg/day) q12h
Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours.
Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours.
Children below 1 year: 25 mg/kg/day in divided doses every 8 hours.
Children over 12 years: IV Injection: 1.2 g every 6-8 hours,
Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants);
Child 3 months-12 years, 30 mg/kg every 6-8 hours.
Mode of Action
Take with meals to avoid GI upset
Take suspension at start of meal to enhance absorption
Reconstitution: Powd for inj: Dissolve amoxicillin/clavulanic acid 500/100 mg in 10 mL solvent and 1,000/200 mg in 20 mL solvent. May further dilute to infusion soln containing either water for inj or NaCl 0.9%.
Precaution
Bacterial infections, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Dental abscess, Community-acquired pneumonia, Acute uncomplicated UTI, Uncomplicated gonorrhea, Severe or recurrent resp tract infections
Side Effect
Renal impairment
CrCl <30 mL/min: Do not use 875/125 mg tablet or extended-release tablets
CrCl 10-30 mL/min: 250-500/125 mg PO q12hr
CrCl <10 mL/min: 250-500/125 mg PO q24hr
Hemodialysis: 250-500/125 mg PO q24hr; administer additional dose both during and at end of dialysis
Pregnancy Category Note
>10%
Diarrhea (3-34%; varies upon dose and regimen)
1-10%
Diaper rash (3.5%),Mycosis (3.3%),Nausea (2-3%),Rash (1-3%),Vomiting (1-2.2%),Loose stool (1.6%),Candidiasis (1.4%),Vaginitis (1%)
<1%
Hypersensitivity reactions,Anaphylaxis,Anemia,Thrombocytopenia,Leukopenia,Agranulocytosis,Hepatoxicity,AST/ALT elevation,Pseudomembranous colitis,Serum sickness,Abdominal discomfort,Cholestatic jaundice,Flatulence
Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
Interaction
Penicillin allergy.
