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AV-5
Drug International Ltd.
Generic: Amlodipine + Valsartan
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with AV-5.
CONSULT YOUR DOCTOR
AV-5 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
AV-5 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
AV-5 may cause side effects which could affect your ability to drive.
AV-5 may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
CAUTION
AV-5 should be used with caution in patients with severe kidney disease. Dose adjustment of AV-5 may be needed. Please consult your doctor.
Regular blood pressure monitoring is recommended. No dose adjustment is needed in patients with mild to moderate kidney disease.
CAUTION
AV-5 should be used with caution in patients with liver disease. Dose adjustment of AV-5 may be needed. Please consult your doctor.
Medicine Overview of AV-5mg+160mg Tablet
Introduction
AV-5 contains two medicines, both of which help to control high blood pressure. It lowers the blood pressure by relaxing the blood vessels and making it easier for your heart to pump blood around your body. This will reduce your risk of having a heart attack or a stroke. AV-5 may be taken on an empty stomach or along with food. However, it is better to take it regularly at a fixed time each day, as prescribed by your doctor. The dose will depend on your condition and how you respond to the medicine. It's important to keep taking this...
... Show moreUses of AV-5
- Hypertension (high blood pressure)
Side effects of AV-5
Common
- Headache
- Dizziness
- Ankle swelling
- Tiredness
- Palpitations
- Increased potassium level in blood
- Sleepiness
- Taste change
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Upset stomach
How to use AV-5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. AV-5 may be taken with or without food, but it is better to take it at a fixed time.
How AV-5 works
AV-5 is a combination of two medicines: Amlodipine and Valsartan, which lowers blood pressure effectively. Amlodipine is a calcium channel blocker (CCB) and Valsartan is an angiotensin receptor blocker (ARB). They work by relaxing the blood vessels and making the heart more efficient at pumping blood throughout the body.
Quick Tips
- Valembic 80 AM Tablet is a combination of two medicines that provides better blood pressure control than either medicine alone.
- Valembic 80 AM Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause you to feel lightheaded or weak especially when you stand up. Rise slowly if you have been sitting or lying down.
- Avoid consuming alcohol as it may enhance the blood pressure lowering effect of this medicine.
- It can cause ankle or foot swelling. Raise your legs while you are sitting down and talk to your doctor if it does not go away.
- Do not take Valembic 80 AM Tablet if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Hypertension Initiate with 5 mg/160 mg PO qDay OR Substitute for individually titrated components May increase dose after at least 2 weeks, not to exceed 10 mg/day amlodipine and 320 mg/day valsartan May be adminsitered concomitantly with other antihypertensive agents Hepatic impairment Not recommended for initial therapy; amlodipine 2.5 mg is not an available strength with available dosage forms for this drug combination Amlodipine: Exposure is increased with hepatic insufficiency, consider decreasing dose Valsartan: Exposure increased with mild-to-moderate hepatic insufficiency does not require dosage adjustment; unknown for severe hepatic impairment Elderly: Since both components of the combination are equally well...
... Show moreAdministration
Amlodipine : Plasma concentrations may be elevated w/ CYP3A4 inhibitors (e.g. azole antifungals, ritonavir). Concomitant therapy w/ simvastatin may increase risk of myopathy including rhabdomyolysis. May increase ciclosporin plasma levels and conivaptan.
Valsartan : May antagonise hypotensive effects and increase the risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics, K supplements or K-containing salt substitutes.
Potentially Fatal: Increased risk of hypotension, hyperkalemia and changes in renal function (including acute renal failure) when used w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
Adult Dose
Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. During the second and third trimesters of pregnancy, these drugs have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death. Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Lactation: discontinue drug or do not nurse
Child Dose
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters).
Renal Dose
Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Valsartan, an angiotensin II type 1 (AT1) receptor antagonist, produces its BP lowering effects by inhibiting angiotensin II-induced vasoconstriction, aldosterone release and renal reabsorption of Na.
Mode of Action
May be taken with or without food.
Precaution
Hypertension
Side Effect
Renal impairment
Mild or moderate (CrCl >30 mL/min): Dose adjustment not necessary
Severe (CrCl <30 mL/min): Not studied
Pregnancy Category Note
>10%
Headache,Increased BUN (6-17%)
1-10%
Peripheral edema (5-8%),Anxiety (3%),Nasopharyngitis (4%),Increased potassium (3%),Upper respiratory infection (3%),Dizziness (2%),Somnolence (3%),Diarrhea (3%),Nausea (3%),Abdominal pain (3%),Cough (2%)
<1%
Orthostatic hypotension,Syncope,Visual disturbance,Tinnitus,Exanthema
Potentially Fatal: Hypotension, bradycardia, conductive system delay and CCF.
Interaction
Known hypersensitivity to dihydropyridines.
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