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Calcium urolithiasis, Cyanide poisoning, Secondary Preventive Treatment for Calciphylaxis in Dialysis Patients
Adult Dose
Oral
A 2 M (molar) solution can be prepared with 74.4 g in 150 mL free water; 2.6 g can be given orally daily or 3 times a week.
Dose is limited by diarrhea.
Contraindication
Oedematous sodium-retaining conditions.
Mode of Action
Thiosulfate is sulfur donor utilized by rhodenase to convert cyanide to less toxic thiocyanate.
Cisplatin toxicity: Na-thiosulfate combines w/ cisplatin to form a complex nontoxic to both normal/cancerous cells. Increases solubility of calcium.
Precaution
May irritate eyes, skin and respiratory tract.
Side Effect
Osmotic disturbances. Oral: catharsis (at high doses).
Interaction
Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.
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