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Zedoxim
Globe Pharmaceuticals Ltd.
Generic: Cefpodoxime
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Zedoxim does not cause any harmful side effects.
SAFE IF PRESCRIBED
Zedoxim is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Zedoxim is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Zedoxim, since it may have possible effects such as rash and diarrhea.
UNSAFE
Zedoxim may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Zedoxim should be used with caution in patients with severe kidney disease. Dose adjustment of Zedoxim may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Zedoxim is safe to use in patients with liver disease. No dose adjustment of Zedoxim is recommended.
Medicine Overview of Zedoxim 40mg/5ml Powder for Suspension
Introduction
Zedoxim is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and skin. It kills bacteria, which helps to improve your symptoms and cure the infection. Zedoxim should be taken with food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a...
... Show moreUses of Zedoxim
- Bacterial infections
Side effects of Zedoxim
Common
- Rash
- Nausea
- Diarrhea
How to use Zedoxim
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zedoxim is to be taken with food.
How Zedoxim works
Zedoxim is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Zedoxim?
If you miss a dose of Zedoxim, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Zedoxim to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Zedoxim and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Take it with food to avoid an upset stomach.
- Avoid consuming alcohol while taking Zedoxim as it may cause increased side effects.
Brief Description
Indication
Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis
Administration
Should be taken with food. Take after meals.
Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis
200 mg PO q12hr for 10 days
Acute Community-Acquired Pneumonia
200 mg PO q12hr for 14 days
Pharyngitis/Tonsillitis
100 mg PO q12hr for 5-10 days
Skin/Skin Structure Infections
400 mg PO q12hr for 7-14 days
Uncomplicated gonorrhoea
200 mg as a single dose
Uncomplicated Urinary Tract Infections
100 mg PO q12hr for 7-14 days
Hepatic impairment
Dosage adjustment not necessary
Child Dose
Child : PO 10 mg/kg/day, max 400 mg/day q12h
6 months - 2 years : 40 mg every 12 hours
3 - 8 years : 80 mg every 12 hours
over 9 years : 100 mg every 12 hours
Renal Dose
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min) Dosage Recommendation
10-39 Increase dosing intervals to 24 hrly.
<10 Increase dosing intervals to 48 hrly.
Contraindication
Hypersensitivity.
Mode of Action
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Side Effect
>10%
Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%)
1-10%
Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%)
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Interaction
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.
Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.
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