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Zoclast
Healthcare Pharmaceuticals Ltd.
Generic: Zoledronic Acid 4mg
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Zoclast. Please consult your doctor.
CONSULT YOUR DOCTOR
Zoclast is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Zoclast is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Zoclast may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Zoclast in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Zoclast in patients with liver disease. Please consult your doctor.
Medicine Overview of Zoclast 4mg/5ml Injection
Introduction
Zoclast is used to treat or prevent weakening of the bones (osteoporosis) caused by menopause or use of steroids. Using this medicine can reduce your risk of breaking bones. It is also used to treat high levels of calcium in people who have cancer. Zoclast is given by a doctor or nurse. How much you are given, and how often, will be decided by your doctor. It may just be a single injection or you may need regular injections depending upon your underlying condition. Your doctor will ask you to drink plenty of water before the injection, to avoid getting...
... Show moreUses of Zoclast
- Osteoporosis
- Hypercalcemia
Side effects of Zoclast
Common
- Headache
- Back pain
- Musculoskeletal (bone, muscle or joint) pain
- Heartburn
- Diarrhea
How to use Zoclast
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Zoclast works
Zoclast is a bisphosphonate. It works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bones and minimizes the risk of fractures.
What if you forget to take Zoclast?
If you miss a dose of Zoclast. Please consult your doctor.
Quick Tips
- You have been prescribed Zoclast for the treatment of osteoporosis.
- It may also be used to treat high blood calcium levels (hypercalcemia) or bone damage and pain that may occur with cancer.
- It is given by injection into a vein, usually over at least 15 minutes or as directed by your doctor.
- Drink plenty of fluids to prevent dehydration and kidney damage.
- It can lower the level of calcium in the blood. Take calcium and vitamin D supplements as suggested by your doctor.
- You may develop fever or flu like symptoms, such as chills, tiredness and weakness. These are usually temporary and should go away after a few days. You may take a pain reliever/fever reducer to prevent or treat these symptoms.
- Zoclast may cause a rare condition called osteonecrosis of the jaw. Have regular dental check-ups and inform your doctor if you develop sudden pain in your jaw.
- Your doctor will monitor your response to Zoclast by testing your bone mineral density (BMD). This is usually done every 1-3 years.
- Do not take Zoclast if you are pregnant or breastfeeding.
Brief Description
Indication
Hypercalcaemia of malignancy, Bone metastases associated with solid tumours, Multiple myeloma
Adult Dose
Intravenous
Hypercalcaemia of malignancy
Adult: 4 mg as a single dose by infusion over at least 15 minutes. Retreatment in patients who relapse or who are refractory to initial treatment: 4 mg as an infusion over at least 15 minutes, after at least 1 wk from initial dose.
Bone metastases associated with solid tumours, Multiple Myeloma;
Adult: 4 mg infusion over at least 15 minutes every 3-4 wk, in conjunction with 500 mg calcium and 400 IU vitamin D oral supplement.
Patients with hepatic impairment
Safety and efficacy not established
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >60 mL/min: 4 mg
CrCl 50-60 mL/min: 3.5 mg
CrCl 40-49 mL/min: 3.3 mg
CrCl 30-39 mL/min: 3 mg
CrCl <30 mL/min: Not recommended
Contraindication
The drug is contraindicated if patients have hypersensitivity to the active substance or to any of the excipients or to any bisphosphonates, hypocalcaemia, renal impairment (creatinine clearance <35 mL/min), current or recent uveitis, or a history of bisphosphonate-associated uveitis, pregnancy and lactation.
Mode of Action
Zoledronic acid, an aminobiphosphonate, is a potent inhibitor of bone resorption. It inhibits osteoclastic activity and skeletal calcium release caused by tumours.
Precaution
Patient w/ aspirin-sensitive asthma. Mild to moderate renal impairment. Pregnancy. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Adequately hydrate patients prior to admin. Ensure adequate Ca and vit D intake. Monitoring Parameters Monitor serum Ca, Mg, phosphate and electrolytes; haematocrit/Hb (oncology use); biochemical markers of bone turnover (non-oncology use). Prior to therapy, perform dental exam and preventive dentistry in patients at risk of osteonecrosis.
Lactation: Unknown whether drug crosses into breast milk; avoid using
Side Effect
Arthralgia, fever, flu-like symptoms, myalgia, headache, pain in extremity, nausea, vomiting, diarrhoea, eye inflammation; alopecia, hyperhidrosis, bone/joint/muscle pain, osteonecrosis of the jaw, femoral fracture, hypersensitivity reactions (e.g. urticaria, angioedema), Stevens-Johnson syndrome, toxic epidermal necrolysis, hypotension.
Potentially Fatal: Severe hypocalcaemia, severe kidney problems.
Interaction
Increased risk of hypocalcaemia with aminoglycosides and loop diuretics. Increased risk renal dysfunction with nephrotoxic agents.
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