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Aminophylline
Ambee Pharmaceuticals Ltd.
Generic: Aminophylline
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Aminophylline. Please consult your doctor.
CONSULT YOUR DOCTOR
Aminophylline may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Aminophylline is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Aminophylline does not usually affect your ability to drive.
CAUTION
Aminophylline should be used with caution in patients with kidney disease. Dose adjustment of Aminophylline may be needed. Please consult your doctor.
CAUTION
Aminophylline should be used with caution in patients with liver disease. Dose adjustment of Aminophylline may be needed. Please consult your doctor.
Medicine Overview of Aminophylline 125mg/5ml Injection
Introduction
Aminophylline is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe. Aminophylline can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should...
... Show moreUses of Aminophylline
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Side effects of Aminophylline
Common
- Headache
- Insomnia (difficulty in sleeping)
- Vomiting
- Nausea
How to use Aminophylline
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aminophylline is to be taken empty stomach.
How Aminophylline works
Aminophylline is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.
Quick Tips
- You have been prescribed Aminophylline for prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD).
- It should be taken at the same time each day, preferably in the evening after food.
- It does not work right away and should not be used to relieve sudden breathing problems. Always keep a fast-acting (rescue) inhaler with you.
- Your doctor may take regular blood test to monitor potassium level and the level of this medicine in your body.
- Notify your doctor if you have ever been diagnosed with kidney, liver or heart disease, or if you have a smoking history. Your dose may need to be adjusted.
- Do not discontinue use without consulting your doctor, even if you feel better.
Brief Description
Indication
Oral
Chronic bronchospasm
Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary.
Intravenous
Acute severe bronchospasm
Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.
Elderly: Dose reduction may be ncessary.
Hepatic impairment: Dose reduction may be ncessary.
Administration
Other xanthines. Clearance reduced by allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-alpha, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, cigarette smoking. Corticosteroids, diuretics, beta2-agonists.
Potentially Fatal: Increased risk of cardiac arrhythmias with sympathomimetics and halothane. Tachycardia with pancuronium. beta-blockers inhibit metabolism. Increased risk of convulsion with quinolones, ketamine.
Adult Dose
Neonates, elderly, lactation, pregnancy, cardiac/hepatic diseases, peptic ulceration, hyperthyroidism, hypertension, epilepsy, heart failure, chronic alcoholism, acute febrile illness.
Renal Dose
Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle. Suggested mechanisms are an increase in intracellular cAMP through inhibition of phosphodiesterase; adenosine receptor antagonism, prostaglandin antagonism and effects on intracellular calcium.
Contraindication
Oral
Chronic bronchospasm
Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.
Intravenous
Acute severe bronchospasm
Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.
Mode of Action
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Precaution
Asthma, Acute bronchospasm, Chronic bronchitis, Emphysema, COPD
Pregnancy Category Note
Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness; tremor, palpitations.
Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV injection.
Interaction
Hypersensitivity.
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