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Pethidine-R

Injection-(100mg/2ml)
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Renata Limited

Generic: Pethidine Hydrochloride

1 Injection
৳ 18.07
৳ 19.88
9% OFF

Medicine Overview of Pethidine-R 100mg/2ml Injection

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Introduction

Pethidine-R is a pain relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment for an extended period of time. Pethidine-R is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

Uses of Pethidine-R

  • Moderate to severe pain

Side effects of Pethidine-R

Common
  • Sleepiness
  • Vomiting
  • Headache
  • Dizziness
  • Nausea
  • Constipation

How to use Pethidine-R

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pethidine-R works

Pethidine-R is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.

What if you forget to take Pethidine-R?

If you miss a dose of Pethidine-R, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • Use Pethidine-R as instructed by your doctor. Never take in greater amounts or more often than prescribed.
  • It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
  • Avoid consuming alcohol when taking the Pethidine-R, as it may cause excessive sleepiness or drowsiness.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Store opioid pain relievers in a safe place and out of reach of others.

Brief Description

Indication

Anaesthesia, Postoperative pain, Moderate to severe acute pain, Obstetric analgesia

Administration

Reconstitution: Dilute with water for inj to a concentration of 5-10 mg/ml.

Adult Dose

Parenteral Moderate to severe acute pain Adult: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr. Obstetric analgesia Adult: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg in 24 hr. As a preoperative medication Adult: 25-100 mg IM/SC given 1 hr before surgery. Postoperative pain Adult: 25-100 mg IM/SC inj every 2-3 hr if necessary. Intravenous Adjunct to anaesthesia Adult: 10-25 mg by slow IV inj. Hepatic impairment: Dose reductions may be necessary.

Child Dose

Parenteral Moderate to severe acute pain Child: SC/IM: 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 20-100 mg. Repeat dose every 4-6 hr if needed. IV inj: Neonates and children >12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. 12-18 yr: 25-50 mg every 4-6 hr if needed. Alternatively, >1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response. As a preoperative medication Child: 1-2 mg/kg given IM 1 hr before surgery. Postoperative pain Child: 0.5-2 mg/kg IM every 2-3 hr if necessary.

Renal Dose

Renal impairment: Dose reductions may be necessary.

Contraindication

Hypersensitivity.

Mode of Action

Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.

Precaution

May impair ability to drive or operate machinery. Hypovolaemia, CV disease; adrenal insufficiency; biliary tract disorder; CNS depression or coma; history of drug abuse or acute alcoholism; head injury, intracranial lesions, elevated intracranial pressure; hepatic or renal impairment; morbidly obese; prostatic hyperplasia; toxic psychoses; pre-existing respiratory compromise (hypoxia and/or hypercapnia), COPD or other obstructive airway disease; sickle-cell disease; supraventricular tachycardia; thyroid dysfunction. Elderly and debilitated patients. Withdraw gradually. Pregnancy (avoid prolonged use or high doses at term) and lactation.

Side Effect

Hypotension; fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, serotonin syndrome; rash, urticaria; nausea, vomiting, constipation, anorexia, stomach cramps, xerostomia, biliary spasm, paralytic ileus, sphincter of Oddi spasm; ureteral spasms, decreased urination; pain at inj site; weakness; dyspnoea; histamine release, physical and psychological dependence.

Pregnancy Category Note

Pregnancy Category B, D if prolonged use/high doses at term.

Interaction

Increased pethidine metabolite levels with aciclovir, cimetidine, ritonavir. Reduced analgesic effects with phenytoin, barbiturates. Additive sedative and/or respiratory depressive effects with alcohol, barbiturates, benzodiazepines, phenothiazines, TCAs, other CNS depressants. Potentially Fatal: Increased risk of serotonin syndrome with MAOIs (not be given concurrently or within 14 days of their discontinuation), serotonin agonists, serotonin reuptake inhibitors, sibutramine, TCAs.

Buy Pethidine-R from Arogga

In Bangladesh, you can get the original Pethidine-R. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Pethidine-R in Bangladesh?

The latest price of Pethidine-R in Bangladesh is 18.07৳. You can buy Pethidine-R at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CAUTION
Caution is advised when consuming alcohol with Pethidine-R. Please consult your doctor.
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CONSULT YOUR DOCTOR
Pethidine-R may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
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SAFE IF PRESCRIBED
Pethidine-R is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
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UNSAFE
Pethidine-R may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
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CAUTION
Pethidine-R should be used with caution in patients with kidney disease. Dose adjustment of Pethidine-R may be needed. Please consult your doctor.
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CAUTION
Pethidine-R should be used with caution in patients with liver disease. Dose adjustment of Pethidine-R may be needed. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.