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Pevaryl
Synovia Pharma PLC.
Generic: Econazole Nitrate 1% topical
Medicine Overview of Pevaryl 1% Cream
বাংলা
English
Indication
Tinea pedis, Tinea cruris, Tinea corporis, Jock itch, Athlet's foot, Pityriasis versicolor, Cutaneous candidiasis, Onychomycoses.
Adult Dose
Topical/Cutaneous
Nail fungal infections
Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk.
Tinea cruris; Tinea versicolor; Tinea corporis
Adult: As 1% cream: Apply once daily for 2 wk.
Cutaneous candidiasis
Adult: As 1% cream: Apply bid (morning and evening) for 2 wk.
Child Dose
<3 months: Safety and efficacy not established
Tinea pedis, cruris, corporis, versicolor:
Apply cream to affected area(s) qDay
Cutaneous candidiasis:
Apply cream to affected area(s) BID
Contraindication
Hypersensitivity.
Mode of Action
Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.
Precaution
Avoid contact with eyes and mucous membranes. Pregnancy.
Lactation: excretion in milk unknown; use with caution
Side Effect
1-10%
Erythema (3%)
Frequency Not Defined
Burning and stinging sensations, Pruritus
Pregnancy Category Note
Pregnancy There are no available data on therapy use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. In animal reproduction studies, econazole nitrate did not cause malformation in mice, rabbits and/or rats at oral doses 80 or 40 times the human dermal dose Animal data Econazole nitrate did not cause malformation in mice, rabbits and/or rats; fetotoxic or embryotoxic effects were observed in oral fertility studies in rats receiving 10 to 40 times the human dermal dose; similar effects were observed in embryofetal and pre- and postnatal developmental studies...
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May enhance anticoagulant effect of warfarin or acenocoumarol.
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