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Safety Advices
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CAUTION
Caution is advised when consuming alcohol with Visudyne. Please consult your doctor.
CONSULT YOUR DOCTOR
Visudyne may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Visudyne is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Visudyne may cause side effects which could affect your ability to drive.
It may cause visual disturbances such as abnormal vision, vision decrease, or visual field defects that may interfere with your ability to drive or use machines.
CONSULT YOUR DOCTOR
There is limited information available on the use of Visudyne in patients with kidney disease. Please consult your doctor.
CAUTION
Visudyne should be used with caution in patients with liver disease. Dose adjustment of Visudyne may be needed. Please consult your doctor.
Medicine Overview of Visudyne 15mg/vial Injection
Introduction
Visudyne is used to treat eye conditions such as wet form of macular degeneration. Visudyne is administered under the supervision of healthcare professionals. Do not self administer this injection. Inform your doctor before taking this injection, if you have any known allergy to it. The common side effects include injection site reaction (pain, swelling, redness) and visual disturbances. However, if you experience these side effects for a longer duration or any other symptoms which you think may be due to this medicine, please inform your doctor. Caution is advised for driving after administration of this injection, as side effects may...
... Show moreUses of Visudyne
- Wet age-related macular degeneration
Side effects of Visudyne
Common
- Injection site reactions (pain, swelling, redness)
- Visual impairment
How to use Visudyne
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Quick Tips
- Visudyne is used for the treatment of eye diseases caused by diabetes, macular degeneration and macular swelling.
- It is administered directly into the eyeball by an eye specialist.
- It may cause temporary visual disturbances. Don't drive or do anything that requires mental focus until you know how Visudyne affects you.
- Inform your doctor if you experience increased eye pain and redness, blurred or decreased vision, or increased sensitivity to light.
Brief Description
Indication
Neovascular age-related macular degeneration
Administration
After IV infusion, eyedrops are used to numb eye
Approximately 15 min after infusion & no later than 5 min after eyedrop application, a special ophthalmic lens is placed over eye
Next the cold laser light spot-sized to match treatment area is applied
Adult Dose
Intravenous
Photosensitiser in the photodynamic therapy of neovascular age-related macular degeneration
Adult: 6 mg/m2 by infusion over 10 min, followed by activation using a laser tuned to a wavelength of 689 nm 15 min after the start of the infusion. Recommended light dose is 50J/cm2, given over 83 sec. Repeat every 3 mth for recurrent choroidal neovascular leakage.
Hepatic impairment: Biliary obstruction; moderate to severe impairment: use with caution as no studies done.
Contraindication
Porphyria; lactation.
Mode of Action
Verteporfin, when activated by low-intensity nonheat-generating laser light at a wavelength corresponding to its absorption peak, generates highly reactive, short-lived singlet O2 and reactive O2 radicals that cause local damage to neovascular endothelium, resulting in vessel occlusion. It appears to accumulate preferentially in the neovasculature e.g. choroidal neovasculature.
Precaution
Moderate to severe hepatic disorders; biliary disorders. Pregnancy. Use the largest arm vein possible (e.g. antecubital) especially in elderly and avoid small veins in the back of the hand. Stop infusion if extravasation occurs and protect extravasation area from direct light and apply cold compresses. Patient to be under close monitoring during verteporfin infusion and exercise caution when general anaesthesia is considered. Avoid exposure of unprotected skin, eyes or other body organs to direct sunlight or bright indoor light for 5 days after treatment. Protect all parts of skin and eyes by wearing protective clothing and dark sunglasses (sunscreens are...
... Show moreSide Effect
Visual disturbances; severe vision loss with or without subretinal or vitreous bleeding; inj site reactions; nausea; photosensitivity; asthenia; cataracts; blepharitis; conjunctivitis; dry eyes; ocular itching; flu-like syndrome; atrial fibrillation; hypertension; peripheral vascular disorder; varicose veins; eczema; constipation; GI cancers; fever; lachrymation disorder; hypersensitivity reactions; increased LFT.
Interaction
Increased rate of verteporfin uptake by the vascular endothelium with calcium channel blockers, polymyxin B or radiation therapy. Increased photosensitivity with photosensitizing agents (e.g. tetracyclines, sulfonamides, phenothiazines, sulfonylurea hypoglycaemic agents, thiazide diuretics and griseofulvin). Decreased verteporfin efficacy with compounds that quench active oxygen species or scavenge radicals e.g. dimethyl sulfoxide, betacarotene, ethanol, formate and mannitol. Decreased verteporfin efficacy with drugs that decrease clotting, vasoconstriction or platelet aggregation e.g. thromboxane A2 inhibitors. Anaesthetics may cause haemodynamic effects.