>10%
Increased liver AST or ALT levels (3-20%; as high as 40-50% in some studies),Hypotension (16%),Dizziness (3-40%),Headache (3-40%),Malaise (3-40%),Abnormal gait/ataxia (3-40%),Fatigue (3-40%),Impaired memory (3-40%),Involuntary movement (3-40%),Sleep disturbances (3-40%),Photosensitivity (10-75%),Hypothyroidism (1-22%),Constipation (10-33%),Anorexia (10-33%)
1-10%
CHF (3%),Bradycardia (3-5%),AV block (5%),SA node dysfunction (1-3%),Hyperthyroidism (3-10%),Hepatitis and cirrhosis (<3%),Visual disturbances (2-9%),Optic neuritis (1%)
Frequency Not Defined
Corneal microdeposits,Demyelinating polyneuropathy
Potentially Fatal: Pulmonary toxicity including pulmonary fibrosis and interstitial pneumonitis, hepatotoxicity, thyrotoxicity. Ventricular arrhythmias, pulmonary alveolitis, exacerbation of arrhythmias and rare serious liver injury. Generally in patients with high doses and having preexisting abnormalities of diffusion capacity.