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Romilast
Labaid Pharmaceuticals Ltd.
Generic: Roflumilast
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Romilast. Please consult your doctor.
CONSULT YOUR DOCTOR
Romilast may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Romilast is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Romilast does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Romilast is safe to use in patients with kidney disease. No dose adjustment of Romilast is recommended.
CAUTION
Romilast should be used with caution in patients with liver disease. Dose adjustment of Romilast may be needed. Please consult your doctor.
Use of Romilast is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Romilast 0.5mg Tablet
Introduction
Romilast is used to prevent chronic obstructive pulmonary disease(COPD), group of lung disorders in which the flow of air to the lungs is blocked and chronic bronchitis. It works by opening the airways and makes breathing easier. Romilast can be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for...
... Show moreUses of Romilast
- Chronic obstructive pulmonary disease (COPD)
Side effects of Romilast
Common
- Headache
- Weight loss
- Dizziness
- Insomnia (difficulty in sleeping)
- Back pain
- Nausea
- Diarrhea
- Decreased appetite
- Flu
How to use Romilast
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Romilast may be taken with or without food, but it is better to take it at a fixed time.
How Romilast works
Romilast works by relaxing the muscles in the walls of the airways. This opens the airways and makes breathing easier.
Quick Tips
- Roflumilast is not effective and should not be used for sudden attacks of breathlessness (acute bronchospasm).
- You should not take roflumilast if you have a history of depression and suicidal behavior/thoughts.
- You should have your weight monitored regularly. Stop taking roflumilast and seek advice if you experience unexplained and significant weight loss while on treatment.
- Roflumilast controls COPD but does not cure it. It is important to continue taking roflumilast even if you feel well unless advised otherwise.
- Roflumilast may cause dizziness, which can aggravate with alcohol intake. Do not drive or operate any machinery until you feel fine.
- You should not take roflumilast if you have any serious disease affecting your immune system (HIV, multiple sclerosis, lupus erythematosus, progressive multifocal leukoencephalopathy) or if you are receiving treatments that act on your immune system for certain cancers or serious infections.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Brief Description
Indication
Chronic obstructive pulmonary disease
Adult Dose
Chronic Obstructive Pulmonary Disease
Reduction of frequency of exacerbations or worsening of symptoms
500 mcg PO once daily
Child Dose
Safety and efficacy not established
Contraindication
Roflumilast is contraindicated to patients with a history of hypersensitivity to Roflumilast or any of other ingredients of the tablet and if a patient has moderate to severe liver impairment.
Mode of Action
Selective phosphodiesterase (PDE)-4 inhibitor; PDE-4 inhibition leads to accumulation of intracellular cyclic adenosine monophosphate (cAMP) in lung tissue and is thought to be underlying mechanism of action.
Precaution
Roflumilast is not a bronchodilator and should not be used for the treatment of a sudden attack of breathlessness. Patients treated with this drug should have their weight monitored regularly. If unexplained or clinically significant weight loss occurs, this should be evaluated, and discontinuation of Roflumilast should be considered. Roflumilast should be given with caution in patients with severe immunological diseases (HIV infection, multiple sclerosis, lupus erythematosus, progressive multifocal leukoencephalopathy and others), severe acute infectious diseases (tuberculosis or acute hepatitis), cancer (except basal-cell carcinoma), and severe impairment of the heart function. Lactation: Probable that roflumilast, its metabolites, or both are...
... Show moreSide Effect
1-10%
Diarrhea (9.5%),Weight loss (7.5%),Nausea (4.7%),Headache (4.4%),Back pain (3.2%),Insomnia (2.4%),Decreased appetite (2.1%),Dizziness (2.1%)
1-10%
Abdominal pain (1-2%),Anxiety (1-2%),Depression (1-2%),Dyspepsia (1-2%),Gastritis (1-2%),Muscle spasms (1-2%),Rhinitis (1-2%),Sinusitis (1-2%),Tremor (1-2%),Urinary tract infection (1-2%),Vomiting (1-2%)
Frequency Not Defined
Suicidality
Interaction
Erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine; rifampicin, phenobarb, carbamazepine, phenytoin, theophylline, OC.
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