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Acuren 50
Incepta Pharmaceuticals Ltd.
Generic: Hydrochlorothiazide
Safety Advices
বাংলা
English
UNSAFE
Acuren 50 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Acuren 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Acuren 50 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Acuren 50 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Acuren 50 should be used with caution in patients with severe kidney disease. Dose adjustment of Acuren 50 may be needed. Please consult your doctor.
Use of Acuren 50 is not recommended in patients with severe kidney disease.
CAUTION
Acuren 50 should be used with caution in patients with liver disease. Dose adjustment of Acuren 50 may be needed. Please consult your doctor.
Medicine Overview of Acuren 50mg Tablet
Introduction
Acuren 50 is a diuretic (water pill) medicine used to treat hypertension (high blood pressure). This medicine reduces excess fluid levels in the body and treats edema (fluid overload) associated with heart, liver, kidney, or lung disease. Acuren 50 makes you lose excess water through urine. It may be used alone or in combination with other medicines. This medicine should be taken only during day time to avoid frequent urination at night. You must take this medicine in the dose and duration as advised by the doctor and never stop it abruptly without consulting the doctor. Most people with high...
... Show moreUses of Acuren 50
- Hypertension (high blood pressure)
Side effects of Acuren 50
Common
- Headache
- Nausea
- Increased blood uric acid
- Decreased potassium level in blood
- Glucose intolerance
- Altered blood lipid level
How to use Acuren 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Acuren 50 is to be taken with food.
How Acuren 50 works
Acuren 50 is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
What if you forget to take Acuren 50?
If you miss a dose of Acuren 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Acuren 50 helps lower blood pressure and also removes excess water from your body.
- Take it in the morning with breakfast to avoid getting up at night to urinate.
- It makes you feel dizzy. Avoid driving and attention requiring activity until you know how it affects you.
- Avoid alcohol intake while taking Acuren 50 as it may increase the dizziness.
- It may cause a sudden drop of sodium level in blood. Avoid low sodium diet while you are taking this medication.
- Monitor your blood pressure after starting Acuren 50, and notify your doctor if it does not lower down.
- Notify your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Hypertension, Congestive heart failure, Oedema, Diabetes insipidus, Renal tubular acidosis
Administration
Should be taken with food.
Adult Dose
Oral
Hypertension
Adult: Initially, 12.5 mg, may increase to 25-50 mg once daily as necessary either alone or w/ other antihypertensives.
Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg.
Oedema
Adult: 25-100 mg daily in 1-2 divided doses or intermittently on alternate days or on 3-5 days a wk.
Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg.
Child Dose
Oral
Hypertension
Child: 2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily.
Oedema
Child: 2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily.
Renal Dose
Renal impairment
CrCl 10 mL/min: Dose adjustment not necessary; not effective with CrCl <30 mL/min unless used in combination with loop diuretic
Contraindication
Hypersensitivity to sulfonamide-derived drugs, anuria, severe renal impairment.
Mode of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Precaution
Patients w/ electrolyte disturbances, history of gout, allergy or bronchial asthma, DM, parathyroid disease, hypercholesterolaemia. May exacerbate SLE. Hepatic and mild to moderate renal impairment. Pregnancy and lactation. Monitoring Parameters Assess wt, input and output reports daily to determine fluid loss, BP, serum electrolytes, BUN, creatinine.
Lactation: Drug excreted in breast milk; use with caution (American Academy of Pediatrics states that it is "compatible with nursing")
Side Effect
Electrolyte disturbances, weakness, hypotension, pancreatitis, jaundice, diarrhoea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, aplastic anaemia, agranulocytosis, leukopenia, haemolytic anaemia, thrombocytopenia, anaphylactic reactions, necrotising angiitis, resp distress, photosensitivity, fever, urticaria, rash, purpura, hyperglycaemia, glycosuria, hyperuricaemia., muscle spasm, vertigo, paraesthesias, dizziness, headache, restlessness, renal failure, renal dysfunction, interstitial nephritis, erythema multiforme, exfoliative dermatitis, alopecia, transient blurred vision, xanthopsia, impotence.
Potentially Fatal: Hypersensitivity reactions.
Interaction
Increases toxicity of lithium. May potentiate orthostatic hypotension w/ barbiturates and narcotics. Enhanced neuromuscular blocking action of competitive neuromuscular blockers (e.g. atracurium). Increased hypokalaemic effect w/ corticosteroids, corticotropin, beta2 agonists (e.g. salbutamol). Additive effect w/ other antihypertensives. Potentiation of orthostatic hypotension w/ barbiturates or opioids. Reduced antihypertensive effect by drugs that cause fluid retention (e.g. corticosteroids, NSAIDs, carbenoxolone). Enhanced nephrotoxicity of NSAIDs. Reduced therapeutic effect of antidiabetics.
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