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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Holoxan.
CONSULT YOUR DOCTOR
Holoxan is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Holoxan is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Holoxan may cause side effects which could affect your ability to drive.
CAUTION
Holoxan should be used with caution in patients with kidney disease. Dose adjustment of Holoxan may be needed. Please consult your doctor.
CAUTION
Holoxan should be used with caution in patients with liver disease. Dose adjustment of Holoxan may be needed. Please consult your doctor.
Medicine Overview of Holoxan 1gm/vial Injection
Introduction
Holoxan is used in the treatment of different kinds of cancers. It is given alone or in combination with other chemotherapy medicines, radiotherapy and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes. Holoxan is usually given as a slow infusion (drip) into a vein (intravenously) over several hours. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in...
... Show moreUses of Holoxan
- Pancreatic cancer
- Ovarian cancer
- Breast cancer
- Non-small cell lung cancer
- Testicular cancer
- Blood cancer
Side effects of Holoxan
Common
- Nausea
- Vomiting
- Anemia (low number of red blood cells)
- Hair loss
- Decreased white blood cell count
- Infection
- Blood in urine
- CNS toxicity
How to use Holoxan
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Holoxan works
Holoxan is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Holoxan?
If you miss a dose of Holoxan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Holoxan is used in combination with other chemotherapy medicines, radiotherapy and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes.
- It is usually given as a slow infusion (drip) into a vein (intravenously) over several hours.
- Drink plenty of fluids while taking this medication to minimise damage to your bladder and kidneys.
- It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
- Use effective measures to avoid pregnancy during treatment with this medicine and for at least 6 months after your last dose as it can be harmful to an unborn baby.
- Your doctor may have your blood tested regularly to monitor your kidney, liver function and levels of blood cells in your blood.
Brief Description
Indication
Breast cancer, Lung cancer, Ovarian cancer, Lymphoma, Testicular cancer, Soft tissue sarcoma, Osteogenic sarcoma, Cervical cancer
Administration
IV Administration
Slow IV infusion over 30 min, or continuous infusion over 5 d
Mesna should be administered concomitantly (20% of the ifosfamide dose 15 min before, 4 hr after, & 8 hr after ifosfamide administration)
Adequate hydration (at least 2 L/day) before & for 72 hr after therapy is recommended to minimize risk of hemorrhagic cystitis
Reconstitution: Add 20 ml of sterile water for inj or sterile bacteriostatic water for inj containing benzyl alcohol or parabens for each 1 g of the drug to produce solutions of 50 mg/ml.
Adult Dose
Intravenous Germ cell testicular carcinoma Adult: 1.2 g/m2/day for 5 days via slow infusion over at least 30 minutes, repeat treatment every 3 wk or after recovery from haematological toxicity. To be given with mesna and adequate hydration of at least 2 L of oral or IV fluid per day. Lymphoma; Sarcoma; Solid tumours Adult: Different licensed dosage regimens are available. Regimen 1: 8-12 g/m2 divided over 3-5 days, repeat course every 2-4 wk. Regimen 2: 6 g/m2 divided over 5 days, repeat course every 3 wk. Regimen 3: 5-6 g/m2 (max: 10 g), give as a single 24-hr infusion,...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min)
<10 Administer 75% of dose.
Contraindication
Hypersensitivity; severe bone-marrow depression. Pregnancy, lactation.
Mode of Action
Ifosfamide is converted to its active metabolites via hepatic microsomal enzymes. These active metabolites act as alkylating agents, disrupting DNA and protein synthesis of the target cells. It is routinely given with mesna to reduce urothelial toxicity.
Precaution
Hepatic or renal dysfunction, compromised bone marrow reserve. Use with mesna and ensure high oral/IV fluid intake to reduce urotoxic effects.
Lactation: excreted in breast milk, do not nurse
Side Effect
>10%
Alopecia (83%),Nausea (58%),Vomiting (58%),Leukopenia (50%),Hematuria (46%),Metabolic acidosis (31%),Thrombocytopenia (20%),CNS toxicity (12%),Neurotoxicity (10-20%)
1-10%
Infection (8%),Nephrotoxicity (6%)
Potentially Fatal: Severe myelosuppression, haemorrhagic cystitis, nephrotoxicity, cardiotoxicity, coma.
Interaction
Causes enhanced toxicity with allopurinol, cisplatin. Ifosfamide enhances the anticoagulant effect of warfarin. CYP2A6 inducers (e.g. amobarbital, pentobarbital, phenobarbital, rifampin and secobarbital) may reduce serum levels of ifosfamide while the inhibitors (e.g. isoniazid, methoxsalen and miconazole) may increase its serum levels. CYP3A4 inducers (e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins) may reduce serum levels of ifosfamide while the inhibitors (e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid) may increase its serum levels.
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