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Sarinex D 2.5
Delta Pharma Limited
Generic: Desloratadine + Pseudoephedrine Sulphate
Medicine Overview of Sarinex D 2.5 Tablet
বাংলা
English
Indication
Allergic rhinitis, Itching, Sneezing, Watery eyes, Runny nose, Hives, Skin rash, Common cold, Nasal congestion
Administration
May be taken with or without food: Swallow whole, do not chew/break/crush.
Adult Dose
PO: Adults: 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly.
1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly.
Hepatic Impairment
Not recommended
Child Dose
PO: Child: 12 years or over : 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly.
1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly.
Renal Dose
Not recommended
Contraindication
Hypersensitivity.
Mode of Action
Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Pseudoephedrine is both an ?-and ?-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. It also directly stimulates ?-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Precaution
Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation.
Lactation: both drugs pass into breast milk, pseudoephedrine is concentrated in breast milk; use caution
Side Effect
>10%
Desloratadine
Fever (12%),Irritability (12%),Headache (12%),Diarrhea (15-21%),Cough (11%),Upper respiratory tract infection (11-21%)
1-10%
Desloratadine
Pharyngitis (4.1%),Dry mouth (3%),Myalgia (2.1%),Emotional lability (3%),Erythema (3%),Macopapular rash (3%),Dizziness (4%),Fatigue (2.1%),Somnolence (2.1%)Urinary tract infection (4%),Dyspepsia (3%),Insomnia (5%),Dysmenorrhea (2.1%)
Frequency Not Defined
Pseudoephedrine
CNS (tremor, restlessness, etc),Insomnia,Arrhythmia,Hypotension,Tachycardia,Fatigue,Rash,Urticaria,Anorexia,Xerostomia,Dysuria,Polyuria,Nausea,Vomiting,Ischemic colitis
Pregnancy Category Note
Pregnancy The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are no adequate and well-controlled studies in pregnant women The majority of studies examining use of pseudoephedrine in pregnancy did not find an association with increased risk of congenital anomalies; a few case-control studies conducted reported potential associations with isolated congenital disorders; however, methodological limitations of these studies made the interpretation of results unreliable Reproductive potential There are no data available on human infertility associated with desloratadine, pseudoephedrine, or combination; there are no animal fertility studies with...
... Show moreInteraction
Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).
Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.
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