Ophthalmic
Ocular infections
Adult: Apply eye drops into the affected eye/s. May be used up to tid.
Contraindication
Hypersensitivity; infants <2 mth.
Mode of Action
Sulfacetamide has bacteriostatic effect on a wide range of gram-positive and gram-negative organisms. It interferes with nucleic acid synthesis thus blocking conversion of PABA to the coenzyme dihydrofolic acid.
Precaution
Elderly. History of allergy or asthma; G6PD deficiency; renal and hepatic impairment. Prolonged therapy requires CBC and urinalysis with microscopic examination. Maintain adequate fluid intake. Pregnancy, lactation.
Action antagonised by PABA and procaine group of local anaesthetics. PABA present in purulent eye exudates can competitively inhibit the action of sulphacetamide.
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