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Antigrain
The Ibn Sina Pharmaceutical Ind. Ltd.
Generic: Pizotifen
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Antigrain. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Antigrain during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Antigrain during breastfeeding is not available. Please consult your doctor.
UNSAFE
Antigrain may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Antigrain should be used with caution in patients with kidney disease. Dose adjustment of Antigrain may be needed. Please consult your doctor.
CAUTION
Antigrain should be used with caution in patients with liver disease. Dose adjustment of Antigrain may be needed. Please consult your doctor.
Medicine Overview of Antigrain 0.5mg Tablet
Introduction
Antigrain is a medicine used for the prevention of migraine. However, it cannot treat an acute attack and will only work to prevent migraines for as long as you continue to take the medicine. This medicine relaxes the brain, preventing migraine headache. Antigrain may be taken with or without food, preferably at night. However, it is advisable to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better. If you have missed...
... Show moreUses of Antigrain
- Migraine
Side effects of Antigrain
Common
- Sleepiness
- Dryness in mouth
- Increased appetite
- Dizziness
- Drowsiness
- Feeling sick
How to use Antigrain
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Antigrain may be taken with or without food, but it is better to take it at a fixed time.
How Antigrain works
Migraine headaches are thought to result from the dilatation of blood vessels in the head. Antigrain is a serotonin antagonist. It works by maintaining the level of serotonin (chemical messenger) in the brain and also prevents loss of tone and dilation of blood vessels, thus preventing the migraine headache.
What if you forget to take Antigrain?
If you miss a dose of Antigrain, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Antigrain for the prevention of migraine headaches.
- Do not take it to treat an acute attack of migraine.
- Some tips that may help avoid a migraine attack:
- It should be taken at night-time before going to bed.
- It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how Antigrain affects you.
- You may experience weight gain while on treatment. Monitoring of body weight is required on a regular basis.
- Notify your doctor if you develop skin rash, muscle aches, tremors, difficulty moving, or abnormal uncontrolled movement.
Brief Description
Indication
Headache, Migraine
Administration
May be taken with or without food.
Adult Dose
Oral
Prophylaxis of migraine; Prophylaxis of cluster headache
Adult: Initially, 0.5 mg, increase gradually as necessary.
Maintenance: 1.5 mg daily as a single dose at night or in 3 divided doses.
Max: 4.5 mg daily (max ?3 mg/dose).
Hepatic impairment: Dose adjustment may be needed.
Child Dose
Oral
Prophylaxis of migraine; Prophylaxis of cluster headache
Child: >2 yr Initially, 0.5 mg. May increase gradually up to 1.5 mg daily in divided doses (max 1 mg/dose).
Renal Dose
Renal impairment: Dose adjustment may be needed.
Contraindication
Premature infants or neonates. Postural giddiness.
Mode of Action
Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.
Precaution
Patient w/ angle-closure glaucoma, urinary retention, epilepsy. Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, somnolence and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor hepatic function (prolonged use), wt gain, BP.
Side Effect
Increased appetite, nausea, wt gain, drowsiness, dizziness, dry mouth, fatigue, muscle pain or cramps, heavy or restless legs, fluid retention, facial flushing, reduced libido, exacerbation of epilepsy, dreaming, hepatic injury.
Interaction
Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides.
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