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Sivolac
Sharif Pharmaceuticals Ltd.
Generic: Lactulose
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Sivolac does not cause any harmful side effects.
SAFE IF PRESCRIBED
Sivolac is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Sivolac is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Sivolac does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Sivolac is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Sivolac may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Sivolac is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Sivolac may not be needed in these patients. Please consult your doctor.
Medicine Overview of Sivolac 3.35gm/5ml Oral Solution
Introduction
Sivolac is a type of sugar used to treat constipation. It is known as a laxative and makes your stool easier to pass by drawing water into your bowel. It is also used to treat hepatic encephalopathy (a liver disease causing confusion, tremor, decreased level of consciousness). Sivolac can be taken with or without food. You should take this medicine as advised by your doctor. Use this medicine regularly to get the maximum benefit and try to take it at the same time(s) each day. Your dose may go up or down depending on how well it is working. Do...
... Show moreUses of Sivolac
- Constipation
- Hepatic encephalopathy
Side effects of Sivolac
Common
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
How to use Sivolac
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Sivolac may be taken with or without food, but it is better to take it at a fixed time.
How Sivolac works
Sivolac works by drawing water into the intestine through osmosis, which makes the stool soft and easier to pass.
What if you forget to take Sivolac?
If you miss a dose of Sivolac, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Sivolac is used in the treatment of constipation and hepatic encephalopathy.
- It should preferably be taken at bedtime as it requires 6 to 8 hours to show effect.
- It is usually taken once a day as needed for up to 2 weeks. Take it exactly as prescribed by the doctor.
- Some healthy tips to prevent constipation from happening:
- Take it atleast 2 hours after taking other medicines, as it may interfere with the absorption of other medicines.
- Inform your doctor if you have a history of stomach disorders such as appendicitis or a blockage in your bowel.
Brief Description
Indication
Constipation, Hepatic encephalopathy
Adult Dose
Constipation
Solution: 15-30 mL (10-20 g) PO once daily; may be increased to 60 mL (40 g) once daily
Portal Systemic Encephalopathy
Prophylaxis
30-45 mL (20-30 g) PO q6-8hr, adjusted until 2-3 soft stools/day; if acute, may be given q1-2hr until 2-3 soft stools/day
Treatment
20-30 g (30-45 mL) PO q1hr to induce rapid defecation; reduced to 20-30 g q6-8hr after defecation achieved; titrated to produce 2-3 soft stools/day
Child Dose
Constipation
0.7-2 g/kg/day (1-3 mL/kg/day) PO in divided doses; not to exceed 40 g/day (60 mL/day)
Portal Systemic Encephalopathy
Prophylaxis
Infants: 2.5-10 mL/day (1.7-6.67 g/day) PO in divided doses; titrated to produce 2-3 soft stools/day
Children and adolescents: 40-90 mL/day (26.7-60 g/day) PO in divided doses; titrated to produce 2-3 soft stools/day
Contraindication
Lactulose is contraindicated in patients with galactosaemia and intestinal obstruction.
Mode of Action
Lactulose promotes peristalsis by producing an osmotic effect in the colon with resultant distention. In hepatic encephalopathy, it reduces absorption of ammonium ions and toxic nitrogenous compounds, resulting in reduced blood ammonia concentrations.
Precaution
It should be used with caution in patients with lactose intolerance and diabetes.
Lactation: Unknown whether drug is distributed into milk; use with caution
Side Effect
Initial dosing may produce flatulence and intestinal cramps, which are usually transient. Excessive dosage can lead to diarrhoea, dehydration, nusea, vomiting, hypokalemia.
Interaction
May prevent release of mesalazine in the colon. Decreased effect with oral neomycin, antacids.
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