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Safety Advices
বাংলা
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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Leukeran. Please consult your doctor.
CONSULT YOUR DOCTOR
Leukeran may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
UNSAFE
Leukeran is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
CONSULT YOUR DOCTOR
It is not known whether Leukeran alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Leukeran should be used with caution in patients with kidney disease. Dose adjustment of Leukeran may be needed. Please consult your doctor.
Careful monitoring by a doctor is important as kidney disease patients are at an increased risk of bone marrow depression and inflammation and infections of urinary bladder while taking this medicine.
CONSULT YOUR DOCTOR
There is limited information available on the use of Leukeran in patients with liver disease. Please consult your doctor.
Medicine Overview of Leukeran 2mg Tablet
Introduction
Leukeran is used in the treatment of some cancers of blood and lymphatic system. It may be also used to treat other kinds of cancer, as determined by the doctor. It is used alone or in combination with other cancer medicines. Leukeran should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it...
... Show moreUses of Leukeran
- Blood cancer
- Hodgkin’s disease
Side effects of Leukeran
Common
- Anemia (low number of red blood cells)
- Decreased blood cells (red cells, white cells, and platelets)
- Decreased white blood cell count (neutrophils)
- Decreased white blood cell count
- Bone marrow suppression
- Nausea
- Vomiting
- Diarrhea
- Mouth ulcer
How to use Leukeran
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leukeran is to be taken empty stomach.
How Leukeran works
Leukeran is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Leukeran?
If you miss a dose of Leukeran, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Leukeran should be taken one hour before a meal or two hours after a meal.
Brief Description
Indication
Lymphocytic leukemia, non-Hodgkin lymphoma, Waldenstrm macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma, nephrotic syndrome, Hodgkin's disease
Administration
Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.
Adult Dose
Chronic Lymphatic (Lymphocytic) Leukemia 0.1 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or 0.03-0.1 mg/kg/day continuously Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes Hodgkin's Lymphoma 0.2 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or 0.03-0.1...
... Show moreRenal Dose
Renal Impairment
<1% (including metabolites) excreted in urine; no dose adjustment required
Contraindication
Hypersensitivity. Pregnancy and lactation. Porphyria.
Mode of Action
Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of the nucleic acid function.
Precaution
Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, myelosuppressive drugs or has a depressed baseline leukocyte/platelet count within the previous 4 wk. Increased incidence of acute leukaemias and other secondary malignancies.
Lactation: not known if excreted in breast milk; do not nurse
Side Effect
>10%
Neutropenia (25-33%),Anemia,Leukopenia,Thrombocytopenia
Frequency Not Defined
Seizures,Hallucinations,Peripheral neuropathy,Nausea,Vomiting,Pulmonary fibrosis,GI effects,Leukemia,Myelosuppression,Hyperuricemia,Infertility,Hepatotoxicity & jaundice,Type I hypersensitivity,Rash,Stevens-Johnson syndrome (rare),Toxic epidermal necrosis (rare),Urticaria,Erythema multiforme (rare),Secondary malignancies
Potentially Fatal: Severe bone marrow suppression, carcinogenic and human infertility.
Pregnancy Category Note
Pregnancy Category: D
Lactation: not known if excreted in breast milk; do not nurse
Interaction
Impairs immune response to vaccines, possible infection after admin of live vaccines.