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Pradox
Beacon Pharmaceuticals PLC
Generic: Pralidoxime Chloride
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Pradox. Please consult your doctor.
CONSULT YOUR DOCTOR
Pradox may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CAUTION
Pradox should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
CONSULT YOUR DOCTOR
It is not known whether Pradox alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Pradox should be used with caution in patients with kidney disease. Dose adjustment of Pradox may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Pradox in patients with liver disease. Please consult your doctor.
Medicine Overview of Pradox 1gm/vial Injection
Introduction
Pradox is a prescription medicine used in the treatment of poisoning caused by pesticides and chemicals that contain organophosphates. It is used in the cases where respiratory depression occurs as a result of muscle weakness due to poisoning. Pradox is administered in a medical emergency situation thus aim should be to seek treatment of poisoning without waiting for the results of laboratory tests. This injection is given under the supervision of a healthcare professional. Moreover, it is important to consult your doctor if you have abnormal heartbeat, difficulty or trouble with breathing, increased muscle weakness, or severe tiredness after receiving...
... Show moreUses of Pradox
- Organophosphate poisoning
Side effects of Pradox
Common
- Accomodation disorder
- Dizziness
- Double vision
- Drowsiness
- Headache
- High blood pressure
- Increased heart rate
- Muscle weakness
- Nausea
How to use Pradox
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Pradox works
Pradox reactivates the enzymes blocked by many pesticides (organophosphates). It is an antidote used in the poisoning of these pesticides.
What if you forget to take Pradox?
If you miss a dose of Pradox, please consult your doctor.
Quick Tips
- Pradox is given as an injection into veins, muscles or under the skin by a doctor only.
- Your doctor will monitor you closely for a period of 72 hours after giving the medicine.
- Your doctor will closely monitor your heart rate, blood pressure, breathing rate and oxygen level during the treatment.
- It may cause temporary blurring of your vision. Do not drive or do anything that requires concentration until you know how it affects you.
Brief Description
Indication
Organophosphorous poisoning, Overdoses of anticholinesterase drugs used in the treatment of, myasthenia gravis.
Administration
IV Preparation
Reconstitute by adding 20 mL SWI to the 1 g vial to provide a 50 mg/mL solution (do not use preservative-containing solutions)
IV Administration
For infusion, dilute required amount of reconstituted solution to 100 mL with NS
Infuse over 15-30 min
May also be given as 5 min slow IVP
IM Administration
1 g vial contents may be reconstituted by adding 3 mL SWI or NS to provide a 300 mg/mL solution
Adult Dose
Organophosphorous Poisoning For IV Infusion: Adults: 1-2 g IV as 15-30 min infusion, repeat a second dose of 1 g to 2 g may be indicated after about one hour if muscle weakness has not been relieved. Additional doses may be given every 10-12 hours if muscle weakness persists. OR Use with atropine, which affects muscarinic receptors; pralidoxime's actions most striking at nicotonic sites (increase muscle strength 10-40 min) For IV Injection: For fluid restricted patient 1 g, should be slowly given (over not less than 5 minutes) by IV injection, as 50 mg/ml solution in normal saline (e.g. 1...
... Show moreChild Dose
Organophosphorous Poisoning For IV Infusion: Children > 16 years of age: 1-2 g IV as 15-30 min infusion, repeat a second dose of 1 g to 2 g may be indicated after about one hour if muscle weakness has not been relieved. Additional doses may be given every 10-12 hours if muscle weakness persists. OR Use with atropine, which affects muscarinic receptors; pralidoxime's actions most striking at nicotonic sites (increase muscle strength 10-40 min) For IV Injection: For fluid restricted patient 1 g, should be slowly given (over not less than 5 minutes) by IV injection, as 50 mg/ml solution...
... Show moreRenal Dose
Renal Impairment: Reduce dose
Contraindication
Carbamate pesticide poisoning, hypersensitivity.
Mode of Action
Pralidoxime reactivates cholinesterase outside the CNS which has been inactivated by phosphorylation due to organophosphate pesticide exposure-resulting. This leads to the destruction of acetylcholine at the neuromuscular junction thus relieving muscle paralysis. It also removes the phosphyl group from the active site of inactivated enzyme which is dependent on the nature of the phosphyl group.
Precaution
The following precautions should be kept in mind in the treatment of acetylcholinesterase poisoning, although they do not bear directly on the use of Pralidoxime Chloride, since barbiturates are potentiated by the anticholinesterases, they should be used cautiously in the treatment of convulsion; morphine, theophylline, aminophylline, succinylcholine, reserpine and phenothiazine-type tranquilizers should be avoided in patients with organophosphate poisoning. Prolonged paralysis has been reported with patients when succinylcholine is given with drugs having anticholinesterase activity; therefore it should be used with cautions. Pregnancy, lactation.
Side Effect
Drowsiness, dizziness, visual disturbances, nausea, tachycardia, headache, hyperventilation and muscle weakness.
Potentially Fatal: Rapid admin causes tachycardia, laryngospasm and rigidity. Large doses cause neuromuscular blockade.
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