Arogga LogoArogga Home
Probis Plus 2.5/6.25 - Image 1
Express delivery icon 12-24 HOURS

ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন

Register
1771 people viewed this
info-icon
info-icon

Probis Plus 2.5/6.25

Tablet-(2.5mg+6.25mg)
brand logo
ACI Limited

Generic: Bisoprolol + Hydrochlorothiazide

10 Tablets (1 Strip)
৳ 54.74
৳ 60.20
9% OFF
Alternative Brands For Probis Plus 2.5/6.25

Medicine Overview of Probis Plus 2.5/6.25 2.5mg+6.25mg Tablet

Switch language Iconবাংলা

Introduction

Probis Plus 2.5/6.25 is a medicine used to treat hypertension (high blood pressure). Probis Plus 2.5/6.25 is a combination of two medicines that helps to control blood pressure when a single medication is not effective. It helps to reduce chances of any future heart attack and stroke. Probis Plus 2.5/6.25 is taken with or without food preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor's advice while taking this medicine. Nausea, constipation, diarrhea, and fatigue are some common side effects of this medicine. Consult your doctor If any of these bother you, or get worse, or Do not go away. Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth and extreme thirst. Dizziness or headache may occur due to low blood pressure but this gets better with time. Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function, blood sugar level and the levels of salts such as potassium or magnesium checked regularly to make sure that this medicine is working properly.

Uses of Probis Plus 2.5/6.25

  • Hypertension (high blood pressure)

Side effects of Probis Plus 2.5/6.25

Common
  • Nausea
  • Constipation
  • Fatigue
  • Headache
  • Diarrhea
  • Dizziness
  • Cold extremities
  • Slow heart rate
  • Increased blood uric acid
  • Decreased potassium level in blood
  • Glucose intolerance
  • Altered blood lipid level
  • Decreased magnesium level in blood
  • Increased calcium level in blood

How to use Probis Plus 2.5/6.25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Probis Plus 2.5/6.25 may be taken with or without food, but it is better to take it at a fixed time.

How Probis Plus 2.5/6.25 works

Probis Plus 2.5/6.25 is a combination of two blood-pressure lowering medicines: Bisoprolol and Hydrochlorothiazide. Bisoprolol is a beta blocker. It works specifically on the heart to improve its efficiency of pumping blood throughout the body. Hydrochlorothiazide is a diuretic which lowers blood pressure by removing extra water from the body. Over time it also relaxes blood vessels and improves blood flow.

Quick Tips

  • It is a combination of two blood pressure lowering medications used for the treatment of high blood pressure.
  • It can be taken with or without food.
  • Do not stop taking Probis Plus 2.5/6.25 suddenly as it can cause your blood pressure to rise suddenly thereby increasing the risk of heart attack and stroke.
  • It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
  • It can hide symptoms of low blood sugar if you're diabetic. Monitor your blood sugar levels regularly.
  • Probis Plus 2.5/6.25 may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.

Brief Description

Indication

Hypertension, Congestive heart failure, HTN, Angina pectoris

Administration

May be taken with or without food.

Adult Dose

Adult: PO Initial: 2.5 mg/6.25 mg tablet once daily. Increase based on clinical response in 2 weeks, Maximum: bisoprolol 20 mg/hydrochlorothiazide 12.5 mg once daily. Elderly: Dosage adjustment for geriatric patients usually not necessary

Renal Dose

Renal Impairment Use caution in dosing/titrating patients with renal dysfunction Cumulative effects of thiazides may develop with impaired renal function CrCl <40mL/min: half-life of bisoprolol fumarate is increased up to threefold

Contraindication

Low cardiac output and uncompensated cardiac failure; sinus bradycardia, 1st ° heart block, cardiogenic shock, bronchospasm; severe haemorrhage. Pregnancy.

Mode of Action

Bisoprolol fumarate/hydrochlorothiazide is a fixed-combination tablet that combines a Beta adrenergic receptor blocker, bisoprolol fumarate, and a thiazide diuretic, hydrochlorothiazide. Bisoprolol fumarate, a cardioselective inhibitor of beta(1)-adrenoceptor, has no significant intrinsic sympathomimetic activity or membrane stabilizing activity in its therapeutic dosage; exhibits beta(2)-adrenoceptors inhibition and negative chronotropic effect. Hydrochlorothiazide is a thiazide diuretic that inhibits Na reabsorption in distal renal tubules resulting in increased excretion of Na+ and water, also K+ and H+ ions.

Precaution

Bronchospastic disease, hyperthyroidism, peripheral vascular disease, undergoing anaesthesia. Monitor blood glucose regularly. May mask symptoms of hypoglycaemia. Elderly. Gradual withdrawal is advised. Lactation: excreted in breast milk, use caution

Side Effect

1-10% Bisoprolol fumarate Arthralgia (3%), asthenia (2%), cough (3%), diarrhea (4%), dizziness (10%), dry mouth (1%), dyspnea (2%), fatigue (8%), headache (11%), hypoaesthesia (2%), insomnia (3%), nausea (2%), peripheral edema (4%), pharyngitis (2%), rhinitis (4%), sinusitis (2%), upper respiratory infection (5%), vomiting (2% ) Hydrochlorothiazide Anorexia,Epigastric distress,Hypokalemia,Hypotension,Orthostatic hypotension,Phototoxicity Frequency Not Defined Bisoprolol fumarate Aggravate CHF, cold extremeties, decrease HDL, depression, hypotension, increase bronchospasm, increase triglycerides, mask symptoms of hypoglycemia, muscle & joint pain Hydrochlorothiazide Agranulocytosis, anaphylaxis, anemia, Confusion, erythema multiforme skin reactions including Stevens-Johnson syndrome Exfoliative dermatitis including toxic epidermal necrolysis, Hypomagnesemia, hyponatremia, hypochloremia, dizziness, fatigue, headache, hypercalcemia, hyperuricemia, hyperglycemia, hyperlipidemia, hypercholesterolemia, muscle weakness or cramps, nausea, purpura, rash, vertigo, vomiting Potentially Fatal: AV block, bradycardia. Rare but may occur in patients with preexisting cardiac disease. Includes severe bronchospasm, hypoglycaemia, hypotension, orthostatic hypotension, bradyarrhythmias. 'Rebound phenomenon' leading to unstable angina or MI on sudden withdrawal.

Pregnancy Category Note

Pregnancy Category: C Lactation: excreted in breast milk, use caution

Interaction

Bisoprolol : May potentiate AV conduction time and may increase negative inotropic effect w/ class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive sympathetic activity. May exacerbate rebound HTN upon discontinuance of clonidine treatment. Increased risk of bradycardia w/ digitalis glycosides. Reduced hypotensive effect w/ NSAIDs. Hydrochlorothiazide: Increases toxicity of lithium. May potentiate orthostatic hypotension w/ barbiturates and narcotics. Enhanced neuromuscular blocking action of competitive neuromuscular blockers (e.g. atracurium). Increased hypokalaemic effect w/ corticosteroids, corticotropin, ?2 agonists (e.g. salbutamol). Additive effect w/ other antihypertensives. Potentiation of orthostatic hypotension w/ barbiturates or opioids. Reduced antihypertensive effect by drugs that cause fluid retention (e.g. corticosteroids, NSAIDs, carbenoxolone). Enhanced nephrotoxicity of NSAIDs. Reduced therapeutic effect of antidiabetics.

Buy Probis Plus 2.5/6.25 from Arogga

In Bangladesh, you can get the original Probis Plus 2.5/6.25. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Probis Plus 2.5/6.25 in Bangladesh?

The latest price of Probis Plus 2.5/6.25 in Bangladesh is 54.74৳. You can buy Probis Plus 2.5/6.25 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

Rocket Icon
UNSAFE
Probis Plus 2.5/6.25 may cause excessive drowsiness with alcohol.
Rocket Icon
CONSULT YOUR DOCTOR
Probis Plus 2.5/6.25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Rocket Icon
CONSULT YOUR DOCTOR
Probis Plus 2.5/6.25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Rocket Icon
CONSULT YOUR DOCTOR
It is not known whether Probis Plus 2.5/6.25 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Rocket Icon
CAUTION
Probis Plus 2.5/6.25 should be used with caution in patients with kidney disease. Dose adjustment of Probis Plus 2.5/6.25 may be needed. Please consult your doctor. Regular blood pressure monitoring is advisable for dose adjustment.
Rocket Icon
CAUTION
Probis Plus 2.5/6.25 should be used with caution in patients with liver disease. Dose adjustment of Probis Plus 2.5/6.25 may be needed. Please consult your doctor.

You May Also Like

see all

More from ACI Limited

see all

Frequently Bought Together

see all
Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.