12-24 Hours
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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Improcal 0.25. Please consult your doctor.
CONSULT YOUR DOCTOR
Improcal 0.25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Improcal 0.25 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Improcal 0.25 does not usually affect your ability to drive.
CAUTION
Improcal 0.25 should be used with caution in patients with severe kidney disease. Dose adjustment of Improcal 0.25 may be needed. Please consult your doctor.
However, regular monitoring of phosphate levels may be advised while you are taking this medicine.
SAFE IF PRESCRIBED
Improcal 0.25 is safe to use in patients with liver disease. No dose adjustment of Improcal 0.25 is recommended.
Medicine Overview of Improcal 0.25
Introduction
Improcal 0.25 is the active form of Vitamin D. It increases the levels of Vitamin D in your blood which in turn raises calcium levels in the blood by helping in absorption of more calcium from your intestine. Thus, it is used in the treatment of calcium deficiency and postmenopausal osteoporosis. Improcal 0.25 is given in women after menopause to strengthen weak bones. It helps in reducing the bone damage. It is administered as an injection. It is advised not to self administer the injection, it should be done by a healthcare professional. In case of injection site reactions such...
... Show moreUses of Improcal 0.25
- Calcium deficiency
Side effects of Improcal 0.25
Common
- Injection site reactions (pain, swelling, redness)
How to use Improcal 0.25
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Improcal 0.25 works
Improcal 0.25 is the active form of Vitamin D. It raises Vitamin D levels in your blood. This in turn raises calcium levels in your blood by helping you absorb more calcium from your intestine.
Quick Tips
- Do not take any other forms of Vitamin D unless your doctor suggests.
- Take calcium supplements along with Vitamin D3 as suggested by your doctor.
- Drink plenty of fluids (such as water) as it is important not to become dehydrated.
- Avoid using antacids without your doctor's advice. Some antacids can make it harder for your body to absorb calcitriol.
- Consult your doctor if you notice a metallic taste in mouth, muscle or joint pain, headache or drowziness.
Brief Description
Indication
Osteoporosis, Hypoparathyroidism, Hypocalcaemia, Osteomalacia rickets, Renal osteodystrophy, Chronic kidney dialysis.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Adult: Capsule: The optimal daily dose of Calcitriol must be carefully determined for each patient on the basis of the serum calcium level. Calcitriol can be administered orally either 0.25 mcg or 0.50 mcg. Postmenopausal osteoporosis The recommended dosage is 0.25 mcg twice daily or 0.50 mcg once daily. Serum creatinine levels should be determined at 4 weeks, 3 and 6 months and 6 monthly intervals thereafter. Renal osteodystrophy (Dialysis patients) The recommended initial dose of Calcitriol is 0.25 mcg/day. Patients with normal or only slightly reduced serum calcium levels may respond to Calcitriol doses of 0.25 mcg every other...
... Show moreChild Dose
Chronic Renal Dialysis Associated Hypocalcemia
0.25-2 mcg/day PO qDay
Hypoparathyroidism/Pseudohypoparathyroidism
6 years: 0.5-2 mcg PO qDay
Familial Hypophosphatemia
Initial: 0.015-0.02 mcg/kg PO qDay
Maintenance: 0.03-0.06 mcg/kg PO qDay
No more than 2 mcg PO qDay
Secondary Hyperparathyroidism in Moderate to Severe Kidney Disease
3 years: 0.25 mcg/day PO; may increase to 0.5 mcg/day
Hypocalcemia in Premature Infants
1 mcg qDay PO for 5 days
Contraindication
Hypercalcaemia; evidence of vitamin D toxicity. Pregnancy (dose exceeding RDA). Lactation.
Mode of Action
Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption..
Precaution
Idiopathic hypercalcaemia. Pediatric doses must be individualised and monitored under close medical supervision. Coronary disease, renal function impairment and arteriosclerosis, especially in the elderly. Hypoparathyroidism.
Excessive dosage of Calcitriol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly.
Patients with normal renal function who are taking Calcitriol should avoid dehydration. Adequate fluid intake should be maintained.
Lactation: Enters breast milk; not recommended
Side Effect
Abdominal pain,Apathy,BUN and creatinine increased,Cardiac arrhythmia,Constipation,Dry mouth,Dehydration,Growth suppression,Headache,Hyperthermia,Hypercalcemia,Hypercholesteremia,Hypermagnesemia,Hyperphosphatemia,Hypertension,Libido decreased,Metallic taste,Muscle or bone pain,Nocturia,Pruritus,Psychosis,Somnolence,Weakness
Pregnancy Category Note
Pregnancy category: C
Lactation: Enters breast milk; not recommended
Interaction
Hypermagnesaemia may develop in patients on chronic renal dialysis. Hypercalcaemia in patients on digitalis may precipitate cardiac arrhythmias. Intestinal absorption of calcitriol may be reduced by cholestyramine and colestipol. Phenytoin, barbiturates may decrease the T1/2 of calcitriol. May develop hypercalcaemia with thiazide diuretics.
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