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Safety Advices
বাংলা
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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Bleocin. Please consult your doctor.
CONSULT YOUR DOCTOR
Bleocin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Bleocin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Bleocin may cause side effects which could affect your ability to drive.
As with $med_name, few people have reported that they feel tired or weak after the treatment so it may affect your driving ability.
CAUTION
Bleocin should be used with caution in patients with kidney disease. Dose adjustment of Bleocin may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Bleocin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bleocin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Bleocin 15mg/vial Injection
Introduction
Bleocin is a medicine used for treatment of cancer in various parts of the body such as cervical, Cancer of the mouth, nasopharynx and paranasal sinuses, larynx, esophagus, and skin. It works by interfering with the growth of cancer cells, which are eventually destroyed. Bleocin may be used alone or with other medicines as part of combination therapy.It is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may...
... Show moreUses of Bleocin
- Cervical cancer
- Cancer of mouth, nasopharynx and paranasal sinuses, larynx, oesophagus
- Skin cancer
Side effects of Bleocin
Common
- Fever
- Hair loss
- Interstitial pneumonia
- Loss of appetite
- Low blood platelets
- Nail discoloration
- Nausea
- Pulmonary fibrosis
- Rigors
- Scratch dermatitis
- Skin pigmentation
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weight loss
How to use Bleocin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Bleocin works
Bleocin is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Quick Tips
- Inform your doctor before taking bleomycin if you have severe heart disease, kidney problems, lung problems requiring use of oxygen, impaired liver function, and chicken pox or if you are about to undergo a surgery.
- Inform your doctor before taking bleomycin if you are taking other anticancer/cytotoxic drugs such as vinca alkaloids or cisplatin, drugs such as clozapine or if you have received radiation in the chest area.
- Seek immediate medical advice if you develop dry cough, breathlessness, rapid breathing or any other lung problems.
- Do not drive or operate heavy machinery after taking this drug as it may make you feel weak or tired.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Brief Description
Indication
Lymphoma, Squamous cell or Testicular tumours, Malignant effusions
Administration
IV/IM Preparation
IV: reconstitute 15 U vial in 5 mL & 30 U vial in 10 mL NS to yield 3 U/mL solution
IM/SC: reconstitute 15 U vial in 1-5 mL & 30 U vial in 2-10 mL NS/SWI/BWI
Do not use dextrose-containing diluents
Although may be stable for longer periods, preferably use within 24 hr of reconstitution
In lymphoma patients, give first 2 doses at 1-2 units to test for anaphylactoid reaction
Limit lifetime dose to <400 units because of risk of pulmonary fibrosis
Low ADRs w/intrapleural administration
Adult Dose
Squamous Cell Carcinoma, Testicular Carcinoma
0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks
Hodgkin's Disease, Non-Hodgkin's Lymphoma
Administer test dose of 1-2 units of bleomycin before first 1-2 doses; monitor vital signs q15min; wait 1 hour minimum before administering remainder of dose; if no acute reaction observe, may administer regular dosage schedule
0.25 to 0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks; reduce to maintenance dose of 1 unit qDay or 5 unit qWeek IV/IM after 50% response
Hepatic Impairment: Dose adjustment not necessary
Child Dose
Not recommended
Renal Dose
Renal Impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 40-50 mL/min: 70% of normal dose
CrCl 30-40 mL/min: 60% of normal dose
CrCl 20-30 mL/min: 55% normal dose
CrCl 10-20 mL/min: 45% normal dose
CrCl 5-10 mL/min: 40% normal dose
Contraindication
Hypersensitivity. Severe pulmonary disease; pregnancy and lactation.
Mode of Action
Bleomycin causes breakage of single- and double- stranded DNA by binding to DNA and inhibiting DNA synthesis. To a lesser extent, it also inhibits RNA and protein synthesis. It causes very little bone marrow suppression.
Precaution
Pulmonary infection, preexisting pulmonary function impairment, renal impairment. Patients who received radiotherapy, particularly to the thorax. Regular chest x-rays should be done. Elderly. Discontinue treatment if chest x-rays show infiltrates or breathlessness occurs.
Lactation: It is not known whether the drug is excreted in milk. Because of the potential for serious adverse reactions in nursing infants, it is recommended that nursing be discontinued by women receiving bleomycin therapy.
Side Effect
>10%
Mucocutaneous toxicity including rash, erythema, hyperpigmentation, urticaria (>50%),Febrile reactions, acute (25-50%),Mucositis (30%),Stomatitis (30%),Interstitial pneumonitis (10%),Pulmonary fibrosis (10%),Anorexia,Weight loss,Rales,Tachypnea
1-10%
Alopecia (1-10%),Fatal pulmonary fibrosis (1%),Confusion,Shivering,Anphylactoid rxns,Onycholysis,Pruritus,Skin thickening,Skleroderma
<1%
Nausea,Malaise,Myocardial infarction,Hypotension,Cerebral vascular accident,Raynaud's phenomenon,Fatal pulmonary fibrosis,Hepatotoxicity,Renal toxicity,Necrolysis,Hyperpigmentation
Potentially Fatal: Pulmonary toxicity, interstitial pneumonitis, fibrosis, cardiorespiratory collapse in patients with lymphoma.
Pregnancy Category Note
Pregnancy Category: D
Lactation: It is not known whether the drug is excreted in milk. Because of the potential for serious adverse reactions in nursing infants, it is recommended that nursing be discontinued by women receiving bleomycin therapy.
Interaction
Increased incidence and severity of lung toxicity w/ previous or concurrent radiotherapy to the chest. Combination w/ vinca alkaloids may result to a syndrome corresponding to morbus Raynaud, ischaemia which can lead to necrosis of peripheral parts of the body (fingers, toes, nose tip). May reduce the absorption of phenytoin. Increased risk of agranulocytosis w/ clozapine.
Potentially Fatal: Increased pulmonary toxicity w/ oxygen, cisplatin or brentuximab.