Introduction
Bromodel is a dopamine agonists and prolactin inhibitors. It is used in the treatment of medical condition occurs as of high level of prolactin such as infertility, or abnormal production of breast milk.
Bromodel should be taken with food, but take it at the same time every day for better results. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Perform regular exercise, follow a diet plan and take other prescribed diabetes medicine while on treatment with this medicine.
The most common side effects of this medicine include nausea, vomiting, headache, fatigue, and hypoglycemia (low blood sugar level). If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Always carry some sugar candy with you to overcome low blood sugar levels. You should avoid drinking alcohol as it can enhance medicine side effects.
Before taking this medicine, tell your doctor if you have ever had liver or kidney disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding.
Uses of Bromodel
- High levels of prolactin
- Female infertility
- Acromegaly
Side effects of Bromodel
Common
- Nausea
- Vomiting
- Headache
- Dizziness
- Fatigue
How to use Bromodel
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bromodel is to be taken with food.
How Bromodel works
Bromodel is a dopamine receptor agonist. It decreases the release of prolactin (milk hormone) in the body. Overproduction of this hormone is associated with abnormal production of breast milk as well as suppression of the sexual glands which can cause infertility. Reducing prolactin levels with Bromodel can therefore improve these conditions. In acromegaly, it works by lowering the amount of growth hormone in the body.
Indication
Parkinson's disease, Galactorrhoea, Hypogonadism, Infertility, acromegaly, Lactation suppression, benign breast and menstrual disorders, Amenorrhea, hyperprolactinaemia
.
Administration
Should be taken with food.
Adult Dose
Adult: PO Parkinson's disease As adjunct to levodopa: 1st wk: 1-1.25 mg at night, 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg twice daily; 4th wk: 2.5 mg 3 times/day, then increase as needed.
Maintenance: 10-40 mg/day.
Hyperprolactinemia
Initial: 1.25-2.5 mg PO qDay
May increase by 2.5 mg/day q2-7Days
Usual therapeutic dosage 5-7.5 mg/day, ranges from 2.5-15 mg/day
Up to 30 mg/day has been used in some patients with amenorrhea &/or galactorrhea
Acromegaly (Parlodel)
1.25-2.5 mg PO qHS for 3 days
May increase by 1.25-2.5 mg/day at q3-7Days
Not to exceed 100 mg/day
Adjunct to surgery and radiotherapy in patients w/ acromegaly Initial: 2.5 mg twice daily, increase slowly, up to 5 mg 6 hrly if needed. Lactation suppression 2.5 mg/day for 2-3 days, up to 2.5 mg twice daily for 14 days.
Prevention of puerperal lactation 2.5 mg on the day of delivery, then 2.5 mg twice daily for 14 days. Cyclical benign breast and menstrual disorders 2.5 mg twice daily.
Hepatic Impairment: Dose adjustment may be necessary; there are no guidelines
Child Dose
Hyperprolactinemia
11-15 years: 1.25-2.5 mg PO qDay (initially)
Maintenance: 2.5-10 mg/day
Contraindication
Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation.
Mode of Action
Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders.
Precaution
Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.
Lactation: should not be used during lactation
Side Effect
>10%
Nausea (49%),Hypotension (30%),Headache (19%),Dizziness (17%)
1-10%
Abdominal cramps,Anorexia,Constipation,Dyspepsia,Dysphagia,Epigastric pain,GI hemorrhage,Vomiting,Drowsiness,Fatigue,Faintness,Hallucinations Visual,Insomnia,Lightheadedness,Nighmares,Paranoia,Psychosis,Seizure,Vertigo,Arrhythmias,Bradycardia,Hypertension,MI,Mottled skin,Orthostasis,Vasospasm,Palpitations,Pericardial effusions,Raynaud's syndrome exacertabtion,Syncope,Blepharospasm,BUN increased,Burning discomfort of the eye,Diplopia,Facial pallor,Leg cramps,Nasal congestion,Rash,Urticaria
Pregnancy Category Note
Pregnancy
Safety of Bromocriptine treatment during pregnancy to the mother and fetus has not been established
If pregnancy occurs during Bromocriptine administration, careful observation of these patients is mandatory
Prolactin-secreting adenomas may expand and compression of optic/other cranial nerves may occur, emergency pituitary surgery becoming necessary; in most cases, the compression resolves following delivery
Reinitiation of Bromocriptine treatment has been reported to produce improvement in the visual fields of patients in whom nerve compression has occurred during pregnancy
In patients being treated for hyperprolactinemia, Bromocriptine should be withdrawn when pregnancy is diagnosed
Acromegaly, prolactinoma, or Parkinson disease
Patients who subsequently become pregnant, determine whether continuing therapy is medically necessary or can discontinues
If it is continued, discontinue therapy in those who may experience hypertensive disorders of pregnancy (including eclampsia, preeclampsia, or pregnancy-induced hypertension) unless withdrawal of Bromocriptine is considered to be medically contraindicated
Lactation
Avoid use during lactation in postpartum women
Interaction
Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics.