Medical Overview
Indication
Treatment or prevention of, Vitamin C Deficiency, Scurvy, Infection, Trauma, Burns, Cold exposure, Following Surgery, common cold, Fever, scurvy, Stress, Cancer, Methaemoglobinaemia and Children receiving unfortified formulas. Also indicated in, Hematuria, Dental Caries, Gum Diseases, Pyorrhea, Acne, Infertility, Atherosclerosis, Fractures, Leg ulcers, Hay fever, Vascular thrombosis prevention, Levodopa toxicity, Arsenic toxicity.
Administration
May be taken with or without food.
IV Preparation
Dilute with large volume of compatible fluid to minimize adverse reactions
Compatible w/ most common diluents (dextrose solns, NS, LR, Ringer's, ½NS, dextrose-saline, dextrose-LR etc)
IV Administration
Avoid rapid infusion
Adult Dose
Oral
Scurvy
Adult: Prevention: 25-75 mg daily. 4 tablets 2 to 3 times daily. Treatment: >250 mg daily, given in divided doses.
May also be given via IM/IV/SC admin.
250-500mg IV qDay/BID for at least 2 weeks.
Thalassaemia
Adult: 100-200 mg daily, to be given with desferrioxamine.
Common cold: 1 gm or more daily in divided doses, i.e. 4 tablets daily.
In wound healing: 2-4 tablets 2 to 3 times daily
In other conditions: 1-2 tablets daily
For the reduction of risk of stroke in the elderly: 1-2 tablets daily.
1 effervescent tablet daily with a meal or as directed by physician. Dissolve one tablet in half glass (100 ml) of water and drink instantly.
Child Dose
Children:
Child: 1 mth-4 yr: 125-250 mg daily;
4-12 yr: 250-500 mg daily;
12-18 yr: 500 mg-1 g daily.
Doses to be given in 1-2 divided doses.
Thalassaemia
Child: 100-200 mg daily, to be given with desferrioxamine.
Metabolic disorders
Child: Neonate: 50-200 mg daily, adjust if needed;
1 mth-18 yr: 200-400 mg daily in 1-2 divided doses, up to 1 g daily may be needed.
Mode of Action
Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.
Precaution
Should be given with caution to patient with hyperoxaluria.
Side Effect
Flushing, Flank pain, Faintness, headache, Diarrhea, dyspepsia, nausea, vomiting, Hyperoxaluria (large doses)
Interaction
Vit C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.